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Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy

ConditionsBilateralUltrasoundIntramuscular Quadratus Lumborum Plane BlockLateral Quadratus Lumborum Plane BlockPostoperative PainCancer PatientsOpen Nephrectomy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorNational Cancer Institute, Egypt

About this trial

This study aims to evaluate the efficacy of bilateral ultrasound-guided intramuscular quadratus lumborum plane block (QL4) versus bilateral lateral quadratus lumborum plane block (QL1) in controlling postoperative pain in cancer patients undergoing open nephrectomy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 18 to 65 years.

Both sexes.

American Society of Anesthesiology (ASA) physical status II-III.

Body mass index (BMI): (20- 40) kg/m2.

Disqualifiers

Patient refusal.

Age <18 years or >65 years

BMI <20 kg/m2 and > 40 kg/m2

Known sensitivity or contraindication to drugs used in the study

Trial design

Design model

Parallel

Treatments tested in this trial

  • Intramuscular quadratus lumborum block

    Drug

    Patients will receive bilateral ultrasound-guided intramuscular quadratus lumborum block with an injection of 0.4 ml/kg bupivacaine 0.25% after induction of general anesthesia

  • Lateral quadratus lumborum block

    Drug

    Patients will receive bilateral ultrasound-guided lateral quadratus lumborum with an injection of 0.4 ml/kg of bupivacaine 0.25 after induction of general anesthesia.

  • General anesthesia

    Drug

    Patients will receive only general anesthesia without any block.

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: Intramuscular quadratus lumborum groupExperimental treatment 1 intervention
Group B: Lateral quadratus lumborum groupExperimental treatment 1 intervention
Group C: Control groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Degree of pain

The degree of pain will be assessed using the Visual Analogue Scale (VAS) where 0 (no pain) and 10 (the worst pain). VAS score in each technique at 0, 2, 4, 8, 12, 16, 20 and 24 hours postoperatively

Time frame
24 hours postoperatively

Secondary outcomes

1

Total amount of morphine consumption

Rescue analgesia will be provided in the form of IV morphine 3 mg boluses if the patient indicates Visual Analogue Scale (VAS) ≥ 4. The total amount of morphine given in 24 hours will be recorded for the two groups. A maximum dose of 0.5 mg/kg/24hours of morphine is allowed.

Time frame
24 hours postoperatively
2

Total amount of fentanyl consumption

Rescue analgesia of fentanyl 1 μg/kg will be given if the mean arterial blood pressure or heart rate rises above 20% of baseline levels.

Time frame
Intraoperatively
3

Change in heart rate

Change in heart rate will be recorded intraoperatively at 5-minute intervals and record the average of each three successive readings, then at 0, 4, 8, 12, 16, 20 and 24 hours postoperatively.

Time frame
24 hours postoperatively
4

Change in mean arterial blood pressure

Change in mean arterial blood pressure will be recorded intraoperatively at 5-minute intervals and record the average of each three successive readings, then at 0, 4, 8, 12, 16, 20 and 24 hours postoperatively.

Time frame
24 hours postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

National Cancer Institute, Egypt

Lead sponsor

Source ClinicalTrials.gov
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