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Blood Flow Restriction and Aerobic Exercise in Iron Deficiency Anemia

ConditionIron Deficiency Anaemia
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-25
SponsorCairo University

About this trial

Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Hb more than 8 and less than 12 in females.

Age: 19-25 year.

BMI ranging from 25 to 29.9 kg/m2.

No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities.

Disqualifiers

unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia.

inherited or acquired red cell disorders (haemoglobinopathies).

acute or chronic infections (malaria, tuberculosis, HIV),.

severe anemia (Hb <8 g/dL).

Trial design

Design model

Parallel

Treatments tested in this trial

  • aerobic exercise + blood flow restriction

    Device

    Twenty five females will be subjected to supervised blood flow restriction combined with aerobic exercise program. participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes .A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. The pressure of the cuff was increased until the participants adapted to the restriction stimulus during the early phase of training, and this pressure was maintained used during the training protocol. The strap pressure was increased by 10 mmHg per week, such that it reached 200 mmHg by the end of 12th week. The pressure on the thigh strap was abruptly released after five completions of the exercise set.

  • aerobic exercise

    Procedure/Surgery

    participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Aerobic Exercise + Blood Flow RestrictionExperimental treatment 1 intervention
Group B: Aerobic ExerciseActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

haemoglobin concentration

Time frame
Baseline and 12 weeks
2

Serum ferritin level

Time frame
Baseline and at 12 weeks
3

Haematocrit

Time frame
Baseline and at 12 weeks
4

Red blood cell (RBC) count

Time frame
baseline and at 12 week

Secondary outcomes

1

Functional capacity assessed using the Incremental Shuttle Walk Test (ISWT)

Time frame
baseline and at 12 week
2

Quality of life assessed using the SF-36 questionnaire

Time frame
baseline and at 12 week
3

Estimated maximal oxygen consumption (VO₂max) derived from the ISWT

Time frame
baseline and at 12 week

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: