About this trial
The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:
* What are the best brain sites to influence the stomach? * What are the effects of different stimulation patterns on stomach activity? * Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?
Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.
Participants will:
* Visit the clinic at least once, and for up to 9 times more over the course of several months. * Receive TMS while sitting in a chair similar to a dentist's chair. * Drink water or consume a test meal during each study visit.
Eligibility criteria
Qualifiers
Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.
Disqualifiers
body mass index (BMI) > 30
pregnancy or intention to become pregnant
past or present chemotherapy
diagnosis of gastric (stomach) cancer
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation, TMS
Treatment groups
Sponsors and collaborators
David Levinthal
Lead sponsor
University of Pittsburgh
Sponsor institution
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator