Brain-Stomach Circuits in Chronic Nausea

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-60
SponsorDavid Levinthal

About this trial

The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:

* What are the best brain sites to influence the stomach? * What are the effects of different stimulation patterns on stomach activity? * Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?

Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.

Participants will:

* Visit the clinic at least once, and for up to 9 times more over the course of several months. * Receive TMS while sitting in a chair similar to a dentist's chair. * Drink water or consume a test meal during each study visit.

Eligibility criteria

Qualifiers

Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.

Disqualifiers

body mass index (BMI) > 30

pregnancy or intention to become pregnant

past or present chemotherapy

diagnosis of gastric (stomach) cancer

Trial design

Treatments tested in this trial

  • Transcranial Magnetic Stimulation, TMS

Treatment groups

219 Participants
are divided into 1 treatment group

Sponsors and collaborators

David Levinthal

Lead sponsor

University of Pittsburgh

Sponsor institution

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator