The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position.
Acute respiratory distress syndrome
Age > 18
Serial arterial blood gas data：PaO2/FiO2 <150. The mechanical ventilator setting：FiO2>0.6, PEEP>5 cmH2O
Implantable electronic devices (e.g., pacemakers)
Body mass index > 30
Major thoracic and abdominal surgery
Patients with unstable spine and pelvis conditions
This study focuses on patients with severe acute respiratory distress syndrome undergoing prone position therapy.
Cohort
Prospective
Electrical Impedance Tomography
DeviceIt utilizes electrical impedance tomography to analyze a series of physiological changes in the lungs following treatment
Prone response
Responder is defined as an increase in PaO2 by 20 mmHg or an increase in PaO2/FiO2 by 20% one hour after receiving prone position therapy
28-day mortality
The mortality status on the 28th day
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