Cardiac Performance Evaluation in Children With Steroid Dependent vs Steroid Resistant Nephrotic Syndrome

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age2-14
SponsorSohag University

About this trial

nephrotic syndrome (NS) is one of the most common pediatric kidney diseases There is an increased incidence of heart disease in patients with primary nephrotic syndrome (PNS) compared to the normal population Conventional Echocardiography is usually utilized to diagnose myocardial dysfunction. Tissue Doppler imaging is a non-invasive cardiac imaging technique which measures the velocity of the longitudinal motion of the mitral annulus, tricuspid annulus and the basal part of interventricular septum

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Children with primary nephrotic syndrome.

Age: 2 - 14 years.

Both males and females

Disqualifiers

Patients of primary cardiac diseases (e.g., congenital or rheumatic heart disease, cardio- myopathy).

Trial design

Design model

Parallel

Treatments tested in this trial

  • Tissue Doppler imaging and Conventional Echocardiography

    Device

    non-invasive cardiac imaging technique which measures the velocity of the longitudinal motion of the mitral annulus, tricuspid annulus and the basal part of interventricular septum

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: group A,Active comparator 1 intervention
Group B: Group BActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

cardiac performance evaluation in children with steroid dependent vs steroid resistant nephrotic syndrome

compairing of myocardial performance index (MPI)(Tei index) in nephrotic dependant and resistant nephrotic syndrom by calculating ejection time (ET) of right and left ventricle and mitral closure time (MCT) using tissue doppler

Time frame
12 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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