Cardiopulmonary Exercise Testing in Lung Cancer Patients Before and During Oncological Treatment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMedical University of Bialystok
About this trial
Patients with lung cancer often have reduced physical fitness and coexisting health problems, which may limit their ability to tolerate oncological treatment. Standard resting lung and heart tests do not always reflect real-life physical capacity during everyday activities or physical effort.
This observational study aims to assess cardiorespiratory fitness in patients with lung cancer before and during standard oncological treatment using cardiopulmonary exercise testing (CPET). CPET is a safe, supervised exercise test that provides objective information on how the heart, lungs, and muscles respond to physical effort.
Participants with WHO/ECOG performance status 0-2 will undergo CPET before treatment initiation and again after the early phase of therapy or surgery. The results may help identify patients with reduced physiological reserve and support individualized monitoring during routine clinical care.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years
Histologically confirmed lung cancer (any stage)
Qualified for standard oncological management (surgery and/or systemic therapy)
WHO/ECOG performance status 0-2
Disqualifiers
Unstable ischemic heart disease
Symptomatic cardiac arrhythmias
Myocarditis or pericarditis
Decompensated heart failure
Trial population
Adult patients (≥18 years) with histologically confirmed lung cancer (any stage) and WHO/ECOG performance status 0-2, treated with standard oncological management in a tertiary university hospital and undergoing cardiopulmonary exercise testing before treatment initiation and after the early phase of therapy or surgery.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Cardiopulmonary Exercise Testing (CPET)
Diagnostic testSymptom-limited cardiopulmonary exercise testing performed using a standardized incremental protocol on a cycle ergometer to assess integrated cardiorespiratory, ventilatory, and metabolic responses to exercise. The test is conducted under continuous medical supervision with electrocardiographic and blood pressure monitoring, in accordance with established safety guidelines and standard termination criteria.
Treatment groups
90 Participants
are divided into 1 treatment groupGroup A: Lung cancer cohort1 intervention
Trial outcomes
Primary outcomes
1
Change in peak oxygen uptake (VO2peak) measured by cardiopulmonary exercise testing
Within-participant change in peak oxygen uptake (VO2peak, mL/kg/min) assessed during symptom-limited cardiopulmonary exercise testing at baseline (before treatment initiation) and at follow-up after the early phase of standard oncological therapy or surgery.
Time frame
Baseline and 6-8 weeks after treatment initiation or approximately 6 weeks after surgerySecondary outcomes
1
Change in anaerobic threshold assessed by cardiopulmonary exercise testing
Within-participant change in anaerobic threshold determined during cardiopulmonary exercise testing between baseline (before treatment initiation) and follow-up after the early phase of standard oncological therapy or surgery.
Time frame
Baseline and 6-8 weeks after treatment initiation or approximately 6 weeks after surgery2
Change in ventilatory efficiency (VE/VCO2 slope) assessed by cardiopulmonary exercise testing
Within-participant change in ventilatory efficiency expressed as the VE/VCO2 slope obtained during cardiopulmonary exercise testing at baseline and follow-up.
Time frame
Baseline and 6-8 weeks after treatment initiation or approximately 6 weeks after surgery3
Change in peak work rate during cardiopulmonary exercise testing
Within-participant change in peak work rate (watts) achieved during cardiopulmonary exercise testing between baseline and follow-up.
Time frame
Baseline and 6-8 weeks after treatment initiation or approximately 6 weeks after surgerySponsors and contacts
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Source ClinicalTrials.gov