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Change in the Phase III Slope of the Volumetric Capnography by Prone Positioning in Acute Respiratory Distress Syndrome

ConditionsAcute Respiratory Distress SyndromeVentilation Perfusion MismatchRespiratory Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorIstanbul University - Cerrahpasa

About this trial

This study evaluates the effects of prone positioning on homogenization of ventilation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ARDS criteria met

intubated and mechanically ventilated as a result of respiratory failure

PaO2/FiO2 <200

Disqualifiers

age older than 18

Chronic pulmonary disease, pneumothoraces, intraabdominal hypertension (> 12 mmHg), pregnancy, not expected to survive >24 hours, hemodynamic instability

Trial population

Adult mixed critical care patients

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Prone Positioning

    Procedure/Surgery

    Patients will be turned to prone position and they will be left in prone position for a duration of at least 16 hours to a maximum of 24 hours. This duration is recommended by the ARDS guidelines.

Treatment groups

60 Participants
are divided into 1 treatment group
Group A: Baseline slope of phase iii1 intervention

Trial outcomes

Primary outcomes

1

Change from baseline in phase iii slope of the volumetric capnograph

phase iii slope is associated with the ventilation homogeneity

Time frame
16 to 24 hours (according to time spent in the prone position)
2

correlation of the phase iii slope with the recruitment to inflation ratio

recruitment to inflation ratio is a simple bedside tool that indicates a higher possible recruitable lung with higher applied Positive End-Expiratory Pressure

Time frame
16 to 24 hours (according to time spent in the prone position)

Secondary outcomes

1

correlation of the phase iii slope with the Partial pressure of the arterial oxygen/ Fraction of inspired O2 concentration (PaO2/FiO2) ratio

PaO2/FiO2 is markedly reduced in ARDS patients as a consequence of aeration loss

Time frame
16 to 24 hours (according to time spent in the prone position)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Istanbul University - Cerrahpasa

Lead sponsor

Source ClinicalTrials.gov
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