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Clinical, Dermoscopic, and Mycological Characteristics of Tinea Capitis in Children

ConditionsFungal Infection by SiteTinea Capitis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-18
SponsorSohag University

About this trial

Tinea capitis is a common dermatophyte infection of the scalp in children aged 0-9 years .The prevalence of tinea capitis in Egypt is 0.4% and higher in public than private schools, Boys were more affected than girls according to children by 5:1 ratio , It is more prevalent in those who live in urban areas, large families, low socioeconomic level, crowded living conditions and immunocompromised people . Tinea capitis is caused by dermatophyte fungi Trichophyton and Microsporum genera. These fungi are classified as: anthropophilic, zoophilic, and geophilic according to the route of infection. These fungi invade the hair shaft in two routes: ectothrix and endothrix . T.tonsurans and T.violaceum are reported to be the most common cause of tinea capitis

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Topical or systemic antifungal medications one month prior to enrollment in the study

Presence of systemic disease, such as hepatic,renal, cardiac, autoimmune diseases, or malignancy

Trial population

The study will be conducted at the Dermatology Outpatient Clinic in Sohag University Hospitals. Study population: The study population will be all patients with tinea capitis both male and female in childhood period, Aged 1-18 years old

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Dermoscopic examination: the findings are divided into pathognomic and non-specific signs

    Diagnostic test

    1. Pathognomic signs: comma hairs, corkscrew hairs, Morse code like hairs and zig-zag hairs. 2. Non-specific signs: black dots, broken hairs, perifollicular scaling and inter follicular erythema

  • Direct Microscopy (KOH) examination

    Diagnostic test

    1. Suspected lesions will be swabbed with 70% ethyl alcohol then scalp scraping using the blunt edge of a sterile surgical blade 2. Skin scales and crusts will be collected from the erythematous, peripheral, actively expanding edges of the lesions onto clean glass slides by scraping the inflamed lesions the scales will contain infected stumps of hair 3. Hair will be removed with the root intact (hair cutting will be avoided) 4. Specimen will be prepared by mounting the sample in (10-30%) of potassium hydroxide with 40% Dimethyle sulphoxide (DMSO) drops on the petri slide to soften the tissue, allowing a thin layer of cells to form.

  • Fungal culture:

    Diagnostic test

    Specimen will be cultured on sabouraud's dextrose agar (SDA) at 25 -30 c for 2 to 4 weeks and another specimen will be cultured on a Dermasel agar base (Oxoid, UK), both supplemented with chloramphenicol and cycloheximide , staining the fungal colonies by Lactophenol cotton blue to help the examination of colonial morphology and microscopic examination of the macro-conidia allow the identification of the dermatophyte species and suitable treatment

  • Antifungal sensitivity:

    Diagnostic test

    Antifungal susceptibility testing will be performed to determine the specific sensitivity profiles of the fungal isolates. Antifungal susceptibility testing will be performed using seven antifungal agents: Terbinafine, Itraconazole, Griseofulvin, Fluconazole, Ketoconazole, Vorioconole and Miconazole. Dermatophytes colonies will be probed from Dermasel agar cultures.

Treatment groups

100 Participants
are divided into 1 treatment group
Group A: patients with tinea capitis both male and female in childhood period4 interventions

Trial outcomes

Primary outcomes

1

Percentage of participants presenting with specific clinical patterns of tinea capitis

Clinical evaluation will be performed to identify and classify the presentation of tinea capitis lesions (e.g., scaly patches, black dots, kerion, favus).

Time frame
At the time of initial clinical evaluation
2

Percentage of participants exhibiting specific dermoscopic features of tinea capitis

Dermoscopic examination using a handheld dermatoscope to identify characteristic signs including comma hairs, corkscrew hairs, broken hairs, and scaling.

Time frame
At the time of initial dermoscopic evaluation
3

Prevalence of isolated fungal species among pediatric tinea capitis cases

Mycological evaluation including direct microscopic KOH preparation and fungal culture on agar media to isolate and identify the causative fungal pathogens.

Time frame
At the time of initial sample collection and culture identification

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sohag University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: