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Clinical Registration Study of Patients With Intracranial / Carotid Stenosis

ConditionsCognitive FunctionStenosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40+
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

About this trial

Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images. The investigators aim to analyze clinical and imaging characteristics of patients with cognitive impairment related to intracranial/carotid stenosis, in order to achieve early identification of cognitive impairment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged ≥ 40 years

≥ 50% stenosis in unilateral intracranial / carotid artery

Written informed consent available

Disqualifiers

Previous history of major head trauma and any intracranial surgery

Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions

Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement

Severe loss of vision, hearing, or communicative ability

Trial population

Patients with intracranial / carotid stenosis aged ≥ 40 years

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • standard medical treatment

    Drug

    standard medical treatment

  • Interventional stenting

    Procedure/Surgery

    Interventional stenting

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Changes in the scores of Mini-mental State Examination

Total score of 30. Higher scores mean a better outcome.

Time frame
2 years

Secondary outcomes

1

Incidence of stroke event including ischemic and hemorrhagic stroke

Time frame
2 years
2

Changes in cerebral glymphatic function

assessed by non-invasive diffusion tensor image analysis along the perivascular space (ALPS-index)

Time frame
2 years
3

Changes in the scores of Montreal Cognitive Assessment

Total score of 30

Time frame
2 years
4

Changes in cerebral blood flow in the territory of the culprit artery

Time frame
2 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Second Affiliated Hospital, School of Medicine, Zhejiang University

Lead sponsor

Source ClinicalTrials.gov
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