Traditional opioid analgesia is a treatment method for moderate to severe pain. However, the use of opioid drugs is not without risks. When treating acute pain, patients may experience hypotension, respiratory depression, hypoxia, nausea and vomiting, irritability, and itching. The purpose of this study is to evaluate the comparison of G protein biased μ - opioid receptor agonist oliceridine and traditional μ - opioid receptor agonist sufentanil in terms of analgesia in patients under general anesthesia.
Age>65 years old
ASA Level I-III
BMI 18.5-29.9
Patients undergoing knee joint surface replacement surgery under general anesthesia
Suffering from chronic pain or mental illness before surgery
Unable to communicate due to cognitive impairment or language barriers before surgery
Patients who have used opioid drugs three days before surgery
Patients with long-term alcohol consumption
Parallel
Oliceridine
DrugThe formula for postoperative analgesia pump is oliceridine 0.4mg · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml.
Sulfentanil
DrugThe analgesic regimen for the sufentanil group is sufentanil 2 µ g · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml.
Measurement of Total Pain Intensity Difference within 48 Hours (SPID-48)
Postoperative pain was evaluated using the NRS Pain Digital Rating Scale at 1, 6, 12, 24, 36, and 48 hours post surgery; Multiply the difference in pain intensity at each post baseline time point within 48 hours (subtracting the pain intensity at a specific post baseline time point from the pain intensity at baseline) by the duration (in hours) of the previous time point, and then add them up.
Adverse reactions
Incidence of nausea, vomiting, dizziness, headache, constipation, itching, and hypoxia
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