Chongqing Adrenogenic Autonomic Cortisol Secretion Cohort Study

ConditionsDiagnosis Treatment Adrenogenic Autonomic Cortisol Secretion

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

AgeNot listed

SponsorChongqing Medical University

About this trial

To investige the etiology, pathogenesis, diagnosis and treatment of adrenogenic autonomic cortisol secretion in Chinese adults.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

CT examination revealed adrenal nodules (maximum diameter ≥10mm);

Serum cortisol > 50nmol/L after 1mg dexamethasone inhibition test (1mg-DST).

Disqualifiers

Patients with primary aldosteronism (PA), pheochromocytoma, adrenal metastatic carcinoma, congenital adrenal hyperplasia (CAH), ganglionic neuroma/paraganglioma, schwannoma, adrenal hematoma and those with no definite diagnosis were evaluated by clinical and endocrine function.

Patients with serious underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamic-pituitary-adrenal axis (HPA axis); Pregnancy.

Patients with a history of alcoholism, fatigue, trauma, infection, depression, glucocorticoid use, and other drugs affecting the function of the hypothalamic-pituitary-adrenal axis.

Patients who are not willing to participate in and complete this study refuse to sign the written informed consent for this study.

Trial population

People with adrenal incidentaloma and serum cortisol \> 50nmol/L after 1mg dexamethasone inhibition test, without other situation mentioned in exclusion criteria.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

200 Participants

are grouped into 2 trial groups

Group A: Study group

Group B: Control group

Trial outcomes

Primary outcomes

SUVmax value of PET-CT

To explore the value of 68\[Ga\]-Pentixafor PET-CT in the diagnosis of MACS

Time frame

10 years

Secondary outcomes

Etiology and pathogenesis of adrenogenic autonomic cortisol secretion

To study the etiology and pathogenesis of adrenogenic autonomic cortisol secretion

Time frame

10 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Chongqing Medical University

Lead sponsor

Source ClinicalTrials.gov

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