Combination of Superior Hypogastric Plexus Block and Transversus Abdominis Plane Block in Abdominal Hysterectomies

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18+
SponsorTanta University

About this trial

This study aims to evaluate the analgesic effect of superior hypogastric plexus block combined with transversus abdominis plane block in abdominal hysterectomies.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years.

American Society of Anesthesiology (ASA) physical status I-II.

Undergoing abdominal hysterectomies under general anesthesia (GA).

Disqualifiers

History of allergies to local anesthetics.

Body mass index (BMI) >35 kg/m2.

Opioid dependency.

Cognitive impairment.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Superior hypogastric plexus block + Transverse abdominis plane

    Other intervention

    Patients will receive superior hypogastric plexus block (SHPB) using 20ml of bupivacaine 0.25%+ transverse abdominis plane (TAP) block using 20ml of bupivacaine 0.25%.

  • Superior hypogastric plexus block

    Other intervention

    Patients will receive superior hypogastric plexus block (SHPB) using 20ml of saline 0.9% (sham)+ transverse abdominis plane (TAP) block using 20ml of bupivacaine 0.25%.

Treatment groups

44 Participants
are divided into 2 treatment groups
Group A: Group SExperimental treatment 1 intervention
Group B: Group CActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Time to the first request for the rescue analgesia

Time to the first request for the rescue analgesia will be recorded from the end of surgery to first dose of morphine administrated.

Time frame
24 hours postoperatively

Secondary outcomes

1

Total morphine consumption

Rescue analgesia of morphine will be given as 3 mg bolus if the numeric rating scale (NRS) \> 3 to be repeated after 30 min if pain persists until the NRS \< 4.

Time frame
24 hours postoperatively
2

Degree of pain

Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS). NRS (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS will be assessed at post-anesthesia care unit (PACU), 2, 4, 6, 8, 12, 18, and 24 h postoperatively.

Time frame
24 hours postoperatively
3

Quality of recovery

The quality of recovery (QoR-15) score will be assessed 24 hours postoperatively. This tool consists of 15 questions, each scored on a 10-point scale, yielding a maximum of 150. It encompasses five domains; physical comfort (questions 1-4, 13), emotional state (questions 9, 10, 14, 15), psychological support (questions 6, 7), physical independence (questions 5, 8), and pain (questions 11, 12).

Time frame
24 hours postoperatively
4

Incidence of adverse events

Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, pruritus, or any other complication will be recorded.

Time frame
24 hours postoperatively

Other outcomes

Sponsors and contacts

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