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Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients

ConditionCARDIOMYOPATHY
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-60
SponsorRiphah International University

About this trial

This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional independence, dyspnea, and blood pressure. However, no significant difference was found between the two groups. The study concludes that both exercise approaches are effective, but longer studies are needed to determine if combined training offers added benefits.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Both male and female Age 40 to 60

Left ventricular ejection fraction <50%

Disqualifiers

Patients diagnosed with valvular heart disease, supraventricular arrhythmias, congenital heart disease were excluded.

Neuromuscular diseases such as stroke, Parkinson.

Underlying pulmonary disease

Impaired cognitive function (14)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Combined Aerobic and Resistance Exercise

    Behavioral

    Participants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups.

  • Aerobic Exercise Only

    Behavioral

    Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.

Treatment groups

66 Participants
are divided into 2 treatment groups
Group A: Combined Aerobic and Resistance Exercise:Experimental treatment 2 interventions
Group B: Aerobic Exercise OnlyActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Functional Independence Measure (FIM) questionnaire

Assesses level of functional independence across self-care, mobility, communication, and social cognition.

Time frame
Baseline and 6 weeks
2

VO₂ Max (Maximum Oxygen Consumption)

Measured using Graded Exercise Test (GXT) to assess cardiovascular fitness.

Time frame
Baseline and 6 weeks.

Secondary outcomes

1

Modified Borg Dyspnea Scale

Rates severity of dyspnea (shortness of breath) from 0 (none) to 10 (maximum).

Time frame
Baseline and 6 weeks.
2

Blood Pressure (Systolic and Diastolic)

Measured via Transthoracic Echocardiogram and standard BP monitor.

Time frame
Baseline and 6 weeks.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Riphah International University

Lead sponsor

Source ClinicalTrials.gov

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