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Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty

ConditionsIntrathecal DexmedetomidineAdductor Canal BlockAnalgesiaTotal Knee Arthroplasty
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorKafrelsheikh University

About this trial

The aim of this work is to evaluate the effect of combined intrathecal dexmedetomidine and adductor canal block for analgesia after total knee arthroplasty (TKA).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 18 to 75 years.

Both sexes.

American Society of Anesthesiology (ASA) physical status I-II.

Scheduled for total knee arthroplasty under spinal anesthesia.

Disqualifiers

Patients with neurological or intellectual disability.

History of allergy to local anesthetics or dexmedetomidine .

Infection at the injection site.

Prolonged use of analgesic or sedative medications.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Intrathecal Dexmedetomidine

    Drug

    Patients will receive 15mg in 3ml hyperbaric bupivacaine intrathecally with 5 μg in 0.5ml dexmedetomidine + adductor canal block using 20 ml saline 0.9% at the end of surgery

  • Adductor Canal Block

    Drug

    Patients will receive 15mg in 3ml hyperbaric bupivacaine intrathecally with 0.5ml saline 0.9% + adductor canal block using 20 ml bupivacaine 0.25% at the end of surgery.

  • Intrathecal Dexmedetomidine + Adductor Canal Block

    Drug

    Patients will receive 15mg in 3ml hyperbaric bupivacaine intrathecally with 5 μg in 0.5ml dexmedetomidine + adductor canal block using 20 ml bupivacaine 0.25% at the end of surgery.

Treatment groups

75 Participants
are divided into 3 treatment groups
Group A: Group ITDExperimental treatment 1 intervention
Group B: Group ACBActive comparator 1 intervention
Group C: Group ITD+ACBExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Total morphine consumption

The patient will receive a 3mg bolus of morphine as a rescue analgesic if the visual analog scale (VAS) was greater than 3, and if the pain persisted for more than 30 mins, the injection was repeated until the VAS became below 4

Time frame
48 hours postoperatively

Secondary outcomes

1

Time to the 1st rescue analgesia

Time to the 1st rescue analgesia will be recorded from the end of surgery till the first dose of morphine administered.

Time frame
48 hours postoperatively
2

Degree of pain

Each patient will be instructed about postoperative pain assessment with the visual analog scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed at 0, 4, 8, 12, 18, 24, 36 and 48 h postoperatively

Time frame
48 hours postoperatively
3

Heart rate

Heart rate will be recorded every 5 minutes till the end of surgery and in post-anesthesia care unit (PACU).

Time frame
In post-anesthesia care unit (PACU) (Up to 1 hour)
4

Mean arterial pressure

Mean arterial pressure will be recorded every 5 minutes till the end of surgery and in post-anesthesia care unit (PACU).

Time frame
In post-anesthesia care unit (PACU) (Up to 1 hour)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kafrelsheikh University

Lead sponsor

Source ClinicalTrials.gov
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