Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUppsala University

About this trial

This study compares three different online psychological treatments for people with clinical burnout (stress-related exhaustion) who are on sick leave or have major difficulties coping at work or in daily life. Many patients with burnout receive broad, recuperation-focused interventions (rest, stress reduction, lifestyle changes), but there is still no clearly evidence-based treatment or agreed clinical model. It is also known that returning to work can be difficult, and there is a need for more structured support.

In this trial, 210 adults in Sweden with clinical burnout will be randomly assigned to one of three 10-week, internet-based treatments:

Online Acceptance and Commitment Therapy (ACT) A structured, values-based CBT approach that focuses on helping participants clarify what matters to them, relate differently to difficult thoughts and feelings, and gradually re-engage in meaningful activities despite exhaustion.

Online Recuperation-focused treatment An active comparison condition that emphasizes rest, recuperation, and healthy daily routines. It provides psychoeducation and practical tools for sleep, relaxation, physical activity, pacing, and balance in everyday life, but does not include ACT-specific methods such as exposure or values work.

Online ACT plus Vocational Support The same ACT program as in group 1, together with three additional sessions with a licensed psychologist focused on work. These sessions help the participant identify work-related barriers, plan a gradual return-to-work (RTW), and formulate a written RTW plan that can be shared with the employer and treating physician.

All three treatments are delivered via a secure digital platform. Participants work through weekly online modules, receive written feedback from a therapist, and have three video sessions during the 10-week period. Clinical psychology students in their final semester deliver the ACT and recuperation treatments, and licensed psychologists deliver the ACT + vocational support condition.

The study has two primary aims:

1. to test whether online ACT reduces self-rated burnout symptoms more than the recuperation-focused treatment at the end of treatment, and 2. to test whether adding structured vocational support to ACT reduces the total number of registered sick-leave days in the year after treatment, compared with ACT alone.

Key secondary outcomes include perceived stress, depression, anxiety, insomnia, everyday memory problems, quality of life, functional impairment, treatment response and remission, treatment credibility and satisfaction, and cost-effectiveness. Outcomes are measured before treatment, weekly during treatment (for selected measures), immediately after treatment, and at 6- and 12-month follow-ups. Sick-leave data are obtained from the Swedish Social Insurance Agency.

To be eligible, participants must be 18 years or older, have symptoms consistent with clinical burnout (including pronounced fatigue and reduced stress tolerance after prolonged psychosocial stress), be on at least 25% sick leave or have marked functional impairment due to these symptoms, have a stable occupation or study situation, and be able to read and write Swedish. People with very long sick leave (more than two years), severe psychiatric conditions (such as severe depression, bipolar disorder, untreated PTSD, or psychosis), current substance abuse, or active suicidal ideation will not be included.

Potential risks include temporary increases in distress, fatigue, or symptom awareness when working with emotions, behavior change, or work-related issues. Participants are monitored closely through weekly questionnaires and therapist contact. If risk for self-harm or serious deterioration is detected, a licensed psychologist will perform a risk assessment and, if needed, refer the participant to appropriate health care.

The hope is that this study will identify effective, scalable, and theory-based online treatments for clinical burnout and clarify whether adding structured vocational support improves long-term work outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18 years or older

Self-reported or clinically verified symptoms consistent with clinical burnout (e.g., pronounced fatigue, cognitive difficulties, and reduced stress tolerance following prolonged psychosocial stress)

Currently on ≥25% sick leave and experiencing significant functional impairment in work or daily life due to these symptoms

Stable occupation or engagement (employment or studies)

Disqualifiers

Sick leave > 2 years for the current episode

Severe acute psychiatric conditions, including: severe depression, bipolar disorder, untreated PTSD, schizophrenia, or other psychotic disorders

Current substance abuse

Active suicidal ideation (as assessed during clinical evaluation)

Trial design

Design model

Parallel

Treatments tested in this trial

  • ACT

    Behavioral

    The ACT intervention targets psychological flexibility using value clarification, functional analysis of stress-maintaining behaviors, mindfulness exercises, and structured exposure to avoidance, perfectionism, and rigid behavioral patterns associated with clinical burnout. The treatment content emphasizes reconnecting with personal values, increasing engagement in meaningful activities, and reducing ineffective coping strategies, such as excessive rest, overcontrol, and avoidance of work-related or emotionally difficult situations.

  • Recuperation

    Behavioral

    The recuperation intervention emphasizes restoring balance through rest, energy management, and healthy daily routines. Core content includes psychoeducation about stress and recovery, sleep hygiene, relaxation and breathing exercises, pacing strategies, gentle physical activity, and establishing structured routines for variation and recuperation. The treatment focuses on supporting restorative habits and reducing overload without using exposure, values work, or other ACT-specific methods.

  • Vocational support

    Behavioral

    The vocational support component provides structured guidance to identify work-related barriers, clarify functional limitations, and develop a realistic, individualized return-to-work (RTW) plan. Content includes mapping job demands, exploring feasible work adjustments, formulating stepwise RTW goals, and identifying supports needed from the employer. Sessions focus on helping the participant create a written RTW plan that can be shared with relevant stakeholders.

Treatment groups

210 Participants
are divided into 3 treatment groups
Group A: Arm 1: ACTExperimental treatment 1 intervention
Group B: Arm 2: RecuperationActive comparator 1 intervention
Group C: Arm 3: ACT + vocational supportActive comparator 2 interventions

Trial outcomes

Primary outcomes

1

Burnout Symptom Severity

This is one of two co-primary outcomes. Burnout symptoms will be assessed using the Shirom-Melamed Burnout Measure-12 (SMBM-12), a 12-item self-report scale measuring the core components of burnout: emotional and physical exhaustion (items 1-6) and cognitive/mental exhaustion (items 7-12). Each item is rated from 1 (almost never) to 7 (almost always). Items are averaged to produce a total mean score ranging from 1 (lowest level of burnout) to 7 (highest level of burnout). Higher scores indicate more severe burnout symptoms. Only the total mean score will be used as the primary outcome. Unit of Measure: SMBM-12 mean total score (1-7)

Time frame
Baseline (Week 0); weekly assessments during treatment (Weeks 1-10); mid-treatment (Week 5); post-treatment (Week 10, primary endpoint); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)
2

Net Sick-Leave Days

This is one of two co-primary outcomes. This outcome reflects the total number of registered sick-leave days during the 12-month period following treatment. Data will be obtained from the Swedish Social Insurance Agency. Part-time sick leave will be converted into net days (e.g., 50% sick leave = 0.5 net day). Higher values indicate worse functional outcome (i.e., more days of sick leave). Unit of Measure: Net sick-leave days (0 to no upper limit)

Time frame
From post-treatment (Week 10) to 12-month follow-up (Month 12 post-treatment)

Secondary outcomes

1

Perceived Stress

Perceived stress will be measured using the Perceived Stress Scale-10 (PSS-10), a 10-item self-report questionnaire assessing the degree to which situations in one's life are appraised as stressful. Items are rated on a 0-4 scale and summed to a total score ranging from 0 (lowest perceived stress) to 40 (highest perceived stress). Higher scores indicate greater perceived stress.

Time frame
Baseline (Week 0); weekly assessments during treatment (Weeks 1-10); mid-treatment (Week 5); post-treatment (Week 10, primary endpoint); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)
2

Anxiety Symptoms Severity

Anxiety severity will be measured using the Generalized Anxiety Disorder-7 (GAD-7), a 7-item self-report questionnaire. Each item is rated from 0 (not at all) to 3 (nearly every day). Items are summed to produce a total score ranging from 0 (no anxiety) to 21 (severe anxiety). Higher scores indicate greater anxiety severity. Unit of Measure: GAD-7 total score (0-21)

Time frame
Baseline (Week 0); mid-treatment (Week 5); post-treatment (Week 10); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)
3

Depressive symptoms severity

Depressive Symptom Severity will be measured using the Patient Health Questionnaire-9 (PHQ-9), a 9-item self-report scale. Each item is rated from 0 (not at all) to 3 (nearly every day). Items are summed to produce a total score ranging from 0 (no depressive symptoms) to 27 (severe depressive symptoms). Higher scores indicate greater depressive symptom severity. Unit of Measure: PHQ-9 total score (0-27)

Time frame
Baseline (Week 0); mid-treatment (Week 5); post-treatment (Week 10); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)
4

Insomnia severity

Sleep disturbance will be measured using the Insomnia Severity Index (ISI), a 7-item self-report scale assessing the severity and impact of insomnia symptoms. Each item is rated on a 0-4 scale, with response options reflecting increasing severity (e.g., from "no problem" to "very severe problem"). Item scores are summed to produce a total score ranging from 0 (no insomnia) to 28 (severe insomnia). Higher scores indicate greater sleep disturbance. Unit of Measure: ISI total score (0-28)

Time frame
Baseline (Week 0); mid-treatment (Week 5); post-treatment (Week 10); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)

Other outcomes

1

Treatment Credibility and Expectancy

Treatment credibility and outcome expectancy will be measured using the Credibility/Expectancy Questionnaire (CEQ), a 6-item self-report measure. Items 1-4 assess treatment credibility, and items 5-6 assess outcome expectancy. The CEQ uses two response formats (rating scales and percentage estimates), and subscale scores are calculated according to CEQ scoring guidelines. Higher scores indicate greater perceived credibility and expectancy. Unit of Measure: CEQ credibility and expectancy subscale scores (higher = greater credibility/expectancy)

Time frame
Week 1; mid-treatment (Week 5)
2

Psychological Flexibility

Psychological flexibility will be assessed using the Psy-Flex scale, a 6-item self-report measure capturing core processes of psychological flexibility. Each item is rated from 1 (very inflexible) to 5 (very flexible). Items are summed to produce a total score ranging from 6 (lowest psychological flexibility) to 30 (highest psychological flexibility). Higher scores indicate greater psychological flexibility. Unit of Measure: Psy-Flex total score (6-30)

Time frame
Baseline (Week 0); weekly during treatment (Weeks 1-10); post-treatment (Week 10); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)
3

Recuperation Behaviors

Recuperation behaviors will be assessed using the Recuperation Behaviors Index (RPI-6), a formative process measure designed to capture multiple distinct aspects of recuperation. The index consists of six items representing complementary recuperation-related skills: detachment, relaxation, pacing, sleep protection, managing obligations, and prioritizing energy-restoring activities. Each item is rated from 1 (not at all true) to 7 (completely true), and items are summed to create a total score. Higher total scores indicate engagement in a broader set of recuperation behaviors. Content validity was established through expert ratings. The RPI-6 is included as a process measure to assess engagement in recuperation behaviors during treatment; full psychometric validation will be conducted in future research. Unit of Measure: RPI-6 total score

Time frame
Baseline (Week 0); weekly during treatment (Weeks 1-10); post-treatment (Week 10); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)
4

Return-to-Work Self-Efficacy

Description: Return-to-work self-efficacy will be assessed using a shortened version of the Self-Efficacy for Return to Work (SE-RTW) scale, originally developed by Lagerveld et al. (2010). The scale measures confidence in handling work demands, managing symptoms at work, and returning to or remaining in employment. Each item is rated on a 1-6 scale, from 1 = "strongly disagree" to 6 = "strongly agree." Items are summed to produce a total score, with higher scores indicating greater return-to-work self-efficacy. Unit of Measure: SE-RTW total score (higher = greater RTW self-efficacy)

Time frame
Baseline (Week 0); weekly during treatment (Weeks 1-10); post-treatment (Week 10); 6-month follow-up (Month 6 post-treatment); 12-month follow-up (Month 12 post-treatment)

Locations

This trial has no locations.

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