Comparing Two Surgical Methods to Prevent Pterygium Regrowth

ConditionPterygium

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorCollege of Physicians and Surgeons Pakistan

About this trial

This study compares two surgical techniques for preventing the regrowth of a pterygium, a non-cancerous growth on the eye. After surgically removing the pterygium, surgeons will cover the area with either a flap of nearby tissue that is rotated into place (Rotational Flap) or with a free graft of tissue taken from under the upper eyelid (Autograft). The main goal is to see which method is better at preventing the pterygium from growing back over a 6-month period. A total of 342 patients with a primary pterygium will be randomly assigned to one of the two surgical groups.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

• Age 18-60

Either gender

Primary pterygium

Disqualifiers

• Collagen vascular disease

Autoimmune disorders

Pregnancy

Ocular surface infection

Trial design

Design model

Parallel

Treatments tested in this trial

Conjunctival Rotational Flap
Procedure/Surgery
A surgical technique where adjacent conjunctival tissue, remaining partially attached, is rotated to cover the exposed sclera after pterygium excision.
Conjunctival Autograft
Procedure/Surgery
A surgical technique where a free graft of conjunctiva is harvested from the superior bulbar conjunctiva and sutured or glued over the scleral defect after pterygium excision

Treatment groups

342 Participants

are divided into 2 treatment groups

Group A: Rotational FlapExperimental treatment 2 interventions

Group B: Conjunctival AutograftActive comparator 2 interventions

Trial outcomes

Primary outcomes

Pterygium Recurrence Rate

Absence of clinical recurrence, defined as a quiet ocular surface with no fibrovascular regrowth ≥ 1 mm onto the cornea, as measured by slit-lamp examination.

Time frame

6 months postoperatively

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

College of Physicians and Surgeons Pakistan

Lead sponsor

Source ClinicalTrials.gov

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