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Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.

ConditionPONV
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorSohag University

About this trial

The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Eligible participants were adults (18-80 years).

Prepared for elective thoracoscopic lobectomy or segmentectomy for lung cancer under general anaesthesia

Disqualifiers

Contraindication to any study drug (e.g., heart block, severe liver disease, allergy).

Chronic opioid use (>30 MME/day for >3 months).

Patients with renal impairment (e GFR <30 mL/min).

Pregnancy.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Opioid Free Anaesthesia

    Drug

    The OFA group protocol consists of a combination of intravenous lidocaine, ketamine, dexmedetomidine, and propofol TIVA.

  • conventential opioid-based anaesthesia (OBA,

    Drug

    The OBA group protocol consists of balanced anaesthesia with fentanyl plus sevoflurane.

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: conventential opioid-based anaesthesia (OBA, n=60).Placebo comparator 1 intervention
Group B: opioid free anesthesia( OFA , n=60)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

the occurrence of PONV during the initial 24 hours

Time frame
24 hours

Secondary outcomes

1

total opioid consumption over 24 hour (expressed as morphine milligram equivalents.

Time frame
24 hours
2

pain intensity scores (numerical rating scale NRS 0-10)

Time frame
24 hours
3

recovery quality (QoR-15 score)

Time frame
24 hours

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sohag University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: