Comparison of Different CSF Sampling Sites on External Ventricular Drains
ConditionCerebrospinal Fluid
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorUniversitaire Ziekenhuizen KU Leuven
About this trial
The aim of the current study is to evaluate the difference between proximal and distal CSF sampling. If the characteristics of distally and proximally sampled CSF are similar or correlate well, it may be possible to only sample CSF distally in the future, thereby avoiding the risks mentioned above.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with an EVD in place regardless of the underlying pathology.
Written informed consent to participate in the study must be obtained from the subject. If the subject is not capable of self-consent, all efforts will be made to locate a legally acceptable representative to act on behalf of the subject.
Disqualifiers
Patients in whom the removal of the drain is planned within 48 hours, before routine sampling, will be excluded.
Trial population
Patients with an external ventricular drain (EVD) presenting to the Neurosurgery ward.
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Analyses of proximal and distal samples
Procedure/SurgeryEvaluate the difference between proximal and distal CSF samples
Treatment groups
55 Participants
are divided into 1 treatment groupGroup A: Patients with EVD1 intervention
Trial outcomes
Primary outcomes
1
Change of the CSF white cell count at day 1-4 and day 5-9 when comparing both sampling methods
The aim of the current study is to evaluate the difference between proximal and distal CSF sampling.
Time frame
Day 1-4 and day 5-9 after placement of EVDSecondary outcomes
1
White cell count correlation for all the available time points
Time frame
Samples will be taken every 2-3 days after placement until removal of EVD (estimated between 7 and 28 days)2
Gram stain correlation for all the available time points
Time frame
Samples will be taken every 2-3 days after placement until removal of EVD (estimated between 7 and 28 days)3
Culture correlation for all the available time points
Time frame
Samples will be taken every 2-3 days after placement until removal of EVD (estimated between 7 and 28 days)4
Protein correlation for all the available time points
Time frame
Samples will be taken every 2-3 days after placement until removal of EVD (estimated between 7 and 28 days)Sponsors and contacts
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Source ClinicalTrials.gov