Health TrialsbyHealthPanel

Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction

ConditionsOverweightOverweight and ObesityAdiposity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorMetropolitan College

About this trial

This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults aged ≥18 years

Body mass index (BMI) ≥25 kg/m²

Greek-speaking (able to read and understand Greek and provide informed consent)

Willing and able to participate in dietary counseling and study assessments for the duration of the study

Disqualifiers

Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications

Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions

Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders

Pregnancy or lactation

Trial design

Design model

Parallel

Treatments tested in this trial

  • Genotype-Based Dietary Counseling

    Behavioral

    This intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period.

  • Standard Dietary Counseling

    Behavioral

    This intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information.

Treatment groups

88 Participants
are divided into 2 treatment groups
Group A: Genotype-Based Dietary CounselingExperimental treatment 1 intervention
Group B: Standard Dietary CounselingActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in Fat Mass (%)

Change in whole-body fat mass percentage from baseline to end of the intervention

Time frame
baseline to end of intervention (12 months)

Secondary outcomes

1

Change in Body Weight

Change in body weight from baseline to end of the intervention

Time frame
baseline to end of intervention (12 months)
2

Change in Lipid Profile

Change in fasting lipid profile parameters (e.g., total cholesterol, LDL-C, HDL-C, triglycerides) from baseline to end of the intervention.

Time frame
baseline to end of intervention (12 months)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Metropolitan College

Lead sponsor

Source ClinicalTrials.gov
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