The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST.
* Primary outcome
• To compare the incidence of POST method. * Secondary outcomes
* Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative. * The hemodynamics recording (HR, BP, MBP, pre and post nebulization) * Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)
Age from 18 to 65 years old.
Both sexes.
American Society of Anesthesiologists (ASA) physical status I-II.
Elective surgery requiring GA with endotracheal intubation.
Surgery involves the oral cavity, nasopharynx, larynx, and neck regions.
Surgery requires prone position.
Surgery lasted more than 3 hours.
History of preoperative sore throat, common cold.
Parallel
Ketamine nebulizer
Drug50 patients will receive preoperative nebulization with 50 mg ketamine in 5 ml normal saline.
Mg sulfate nebulizer
Drug50 patients will receive preoperative nebulization with 250 mg magnesium sulfate in 5 ml normal saline.
Placebo
Drug50 patients will receive preoperative nebulization with 5 ml normal saline.
To compare the incidence of Post operative sore throat method.
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