Comparison of Two Sedative Agents in Terms of Controlled Hypotension

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorHayatabad Medical Complex

About this trial

Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention. So, it provides a better visiblity of surgical filed to the surgeons.This RCT compares propofol infusion vs isoflurane inhalation for inducing controlled hypotension during endoscopic sinus surgery. The goal is to assess which agent better controls blood pressure, improves surgical field visibility, and impacts recovery. It likely measures outcomes like hemodynamics, bleeding, and surgeon satisfaction.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Either male/female Age 18-65 Patients undergoing endoscopic sinus surgery as per the operational definition

Disqualifiers

Patients with cardiovascular disease Patients with pregnancy Patients with coagulopathy Patients on beta blockers or calcium channel blockers

Trial design

Design model

Parallel

Treatments tested in this trial

  • Propofol

    Drug

    Intravenous propofol infusion (starting dose 12mg/kg/hr and titrated accordingly) given to patients as sedative undergoing endscopic sinus surgery for hemodynamic stability

  • Isoflurane

    Drug

    Isoflurane inhalation (1-2% end tidal) used in patients as sedative undergoing endoscopic sinus surgery for hemodynamic stability

Treatment groups

136 Participants
are divided into 2 treatment groups
Group A: Patient receiving Propofol infusion for controlled hypotention during surgery under general anaesExperimental treatment 1 intervention
Group B: Isoflurane inhalation for controlled hypotension during surgery under general anaesthesiaActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Surgical field visibility

Time frame
The surgical field visibility time frame for propofol vs isoflurane during endoscopic sinus surgery assessed intraoperatively is usually 30-60mins postinduction
2

Surgical field visibility

Time frame
The surgical field visibility time frame assessed intraoperatively during endoscopic sinus surgery is usually 30- 60 mins post induction

Secondary outcomes

Other outcomes

Sponsors and contacts

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