Computer-Assisted Comparison of Hip Socket Volume and Surface Shape After Pediatric Acetabular Osteotomies

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age2-18
SponsorIstanbul University

About this trial

The goal of this observational study is to learn how four acetabular osteotomy techniques change the shape of the hip socket in children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia.

The main questions it aims to answer are:

How do virtual Salter, Dega, San Diego, and Pemberton osteotomies differ in acetabular volume and surface shape on participant-specific three-dimensional models? How closely does the virtual result of the osteotomy actually performed match the early postoperative magnetic resonance imaging (MRI)?

Participants will have a three-dimensional pelvis-acetabulum model created from preoperative MRI. Researchers will perform virtual Salter, Dega, San Diego, and Pemberton osteotomies on that model and measure the resulting acetabular morphology. The virtual result of the osteotomy actually performed will then be compared with the participant's early postoperative MRI.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 2 to 18 years

Developmental dysplasia of the hip or residual acetabular dysplasia

Primary Salter, Dega, San Diego, or Pemberton acetabular osteotomy planned at Istanbul University, Istanbul Faculty of Medicine

Preoperative hip MRI available within 6 weeks before surgery

Disqualifiers

Hip pathology not related to developmental dysplasia of the hip, including Perthes disease, slipped capital femoral epiphysis, neuromuscular dysplasia, or infection/trauma sequelae

Previous surgery on the same hip that significantly alters anatomy, including prior pelvic or femoral osteotomy or open reduction, or current metal implant/fusion

MRI contraindication or safety issue, including MR-incompatible implant/device, severe claustrophobia, or a medical barrier to sedation/anesthesia

MRI not compatible with protocol or inadequate for analysis

Trial population

Children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia who are scheduled for primary Salter, Dega, San Diego, or Pemberton acetabular osteotomy at Istanbul University, Istanbul Faculty of Medicine

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Salter osteotomy

    Procedure/Surgery

    Redirectional innominate osteotomy performed to improve acetabular orientation and femoral head coverage in children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia. The acetabulum is reoriented as a single fragment to increase primarily anterolateral coverage. The procedure is performed as routine clinical care, with technique selection based on the treating surgeon's indication and preoperative deformity pattern.

  • Dega osteotomy

    Procedure/Surgery

    Incomplete transiliac acetabuloplasty performed to reshape the acetabular roof and improve femoral head coverage in children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia. The osteotomy preserves a hinge at the triradiate cartilage, allowing tailored correction of acetabular deficiency according to the morphology of the dysplastic socket. The procedure is performed as routine clinical care, with technique selection based on the treating surgeon's indication and preoperative deformity pattern.

  • San Diego osteotomy

    Procedure/Surgery

    Incomplete transiliac acetabuloplasty performed to improve acetabular coverage in children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia. The procedure preserves a triradiate cartilage hinge and allows directional correction according to the location of acetabular deficiency, including posterolateral or lateral deficiency when appropriate. The procedure is performed as routine clinical care, with technique selection based on the treating surgeon's indication and preoperative deformity pattern.

  • Pemberton osteotomy

    Procedure/Surgery

    Pericapsular acetabuloplasty performed to reshape and redirect the acetabulum in children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia. The osteotomy uses the triradiate cartilage as a hinge and increases femoral head coverage by altering acetabular shape and orientation. The procedure is performed as routine clinical care, with technique selection based on the treating surgeon's indication and preoperative deformity pattern.

Treatment groups

12 Participants
are divided into 4 treatment groups
Group A: Salter Osteotomy Cohort1 intervention
Group B: Dega Osteotomy Cohort1 intervention
Group C: San Diego Osteotomy Cohort1 intervention
Group D: Pemberton Osteotomy Cohort1 intervention

Trial outcomes

Primary outcomes

1

Osteotomy-type differences in simulated acetabular morphometry

Comparison across virtual Salter, Dega, San Diego, and Pemberton osteotomies of predefined morphometric outputs on participant-specific preoperative 3-dimensional models, including acetabular volume (mm3), surface area (mm2), and angular parameters such as version and inclination (degrees).

Time frame
Baseline (preoperative MRI-based virtual simulation, within 6 weeks before surgery)
2

Virtual-to-actual agreement of postoperative acetabular morphometry for the clinically performed osteotomy

Agreement between the matched virtual osteotomy and the actual postoperative morphology, assessed using predefined morphometric outputs including acetabular volume (mm3), surface area (mm2), and angular parameters such as version and inclination (degrees); summarized using absolute difference, bias, and Bland-Altman limits of agreement.

Time frame
Baseline and early postoperative MRI (3 to 8 weeks after surgery)

Secondary outcomes

1

Osteotomy-type differences in virtual-to-actual prediction error

Comparison of validation error among clinically performed Salter, Dega, San Diego, and Pemberton osteotomies.

Time frame
Baseline and early postoperative MRI (3 to 8 weeks after surgery)
2

Interobserver reliability of MRI-based segmentation and morphometric measurements

Interobserver agreement for segmentation and morphometric measurements, reported using intraclass correlation coefficients.

Time frame
Baseline and early postoperative MRI (3 to 8 weeks after surgery)
3

Intraobserver reliability of MRI-based segmentation and morphometric measurements

Intraobserver agreement for repeat measurements, reported using intraclass correlation coefficients.

Time frame
Baseline and early postoperative MRI (3 to 8 weeks after surgery)
4

Workflow processing time

Time required for segmentation, virtual osteotomy simulation, and morphometric analysis.

Time frame
From baseline MRI acquisition to completion of early postoperative MRI analysis, up to 14 weeks

Other outcomes

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