Health TrialsbyHealthPanel

Continuous vs. Intermittent Rt-fMRI Neurofeedback Training of the Anterior Insula

ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorUniversity of Electronic Science and Technology of China

About this trial

The main aim of this study is to compare the efficacy of intermittent with continuous real-time functional magnetic resonance imaging (fMRI) neurofeedback on anterior insula regulation and associated behavioral changes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • real-time fMRI neurofeedback training procedure

    Procedure/Surgery

    real-time fMRI neurofeedback training procedure running on the Turbo Brain voyager (TBV) 4.2 software (Brain Innovation, Maastricht, The Netherlands)

  • real-time fMRI sham-controlled neurofeedback training procedure

    Procedure/Surgery

    real-time fMRI sham neurofeedback training procedure running on the Turbo Brain voyager (TBV) 4.2 software (Brain Innovation, Maastricht, The Netherlands)

  • real-time fMRI neurofeedback training procedure

    Procedure/Surgery

    real-time fMRI neurofeedback training procedure running on the Turbo Brain voyager (TBV) 4.2 software (Brain Innovation, Maastricht, The Netherlands)

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: Intermittent neurofeedback trainingExperimental treatment 1 intervention
Group B: Intermittent sham controlSham comparator 1 intervention
Group C: Continuous neurofeedback trainingExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Neural activity of the anterior insula based on blood oxygen level-dependent (BOLD) signal

The anterior insula activity induced during the regulation block compared to the baseline block.

Time frame
1 hour
2

Pain empathy ratings scores

Subjects were required to rate their empathic feeling towards painful pictures on a Likert Scale ranging from 1-9 (1 = not at all and 9 = very painful) before and after neurofeedback training.

Time frame
1 hour

Secondary outcomes

1

Confidence rating scores of interoceptive sensitivity

Subjects are asked to rate to what extent they can feel their heartbeat based on a Likert Scale ranging from 1-9 (1 = very low and 9 = very high)

Time frame
1 hour
2

Interoceptive accuracy

1/N Σ(1-(\|actual heartbeats--reported heartbeats\|) / actual heartbeats). N indicates the number of recording blocks.

Time frame
10 minutes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Electronic Science and Technology of China

Lead sponsor

Source ClinicalTrials.gov
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