CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-60
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.

this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.

Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

from 40 to 60 years

follow-up in the pneumology unit of CHU Amiens - Picardie

Chronic Obstructive Pulmonary Disease stade II

Body mass index from 20 to 30 kg.m-2

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Normobaric hypoxia

    Other intervention

    Normobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods

  • normoxic condition

    Other intervention

    Between-sets recovery periods under normoxic condition

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: comparatorExperimental treatment 1 intervention
Group B: shamSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Perception Exertion score with CR10

The modified Borg CR10 RPE scale measures exertion on a scale of 0 (no exertion or resting) to 10 (pushing yourself to the max).

Time frame
day 1

Secondary outcomes

1

Cardiorespiratory responses to exercise

Cardiorespiratory responses to exercise is measured with gaseous exchange volumes

Time frame
day 1

Other outcomes

Sponsors and contacts

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