D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSohag University
About this trial
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria.
Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial.
Hemodynamically stable without significant vasopressor support.
Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O .
Disqualifiers
Refusal of consent
Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis.
Large pneumothorax or pathology interfering with ultrasound assessment.
Terminal extubation.
Trial population
Mechanically ventilated adult COPD patients admitted to the intensive care units of Sohag University Hospitals and fulfilling standard weaning readiness criteria.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
100 Participants
are grouped into 1 trial groupGroup A: Mechanically Ventilated COPD Patients
Trial outcomes
Primary outcomes
1
AUROC of D-RSBI for prediction of successful weaning
Area under the receiver operating characteristic curve (AUROC) of diaphragmatic rapid shallow breathing index (D-RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.
Time frame
Within 72 hours after extubationSecondary outcomes
1
AUROC of conventional RSBI for prediction of successful weaning.
Area under the receiver operating characteristic curve (AUROC) of conventional rapid shallow breathing index (RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.
Time frame
Within 72 hours after extubation2
Difference between AUROC values of D-RSBI and conventional RSBI
Comparison between AUROC values of D-RSBI and conventional RSBI for prediction of successful weaning.
Time frame
Within 72 hours after extubationSponsors and contacts
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Source ClinicalTrials.gov