Health TrialsbyHealthPanel

Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites

ConditionsSocket PreservationAlveolar Ridge Preservation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorCairo University

About this trial

When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction:

Demineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove minerals while keeping bone-forming proteins.

Mineralized Plasmatic Matrix (MPM): A mixture of a standard bone substitute and platelet-rich plasma from the patient's blood.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)

    Biological/Vaccine

    Autogenous dentin-derived grafting material is used as a bone substitute for alveolar ridge preservation following molar extraction. PRF, obtained from the patient's centrifuged blood, is mixed with DDM to enhance graft stability and promote healing.

  • Mineralized Plasmatic Matrix (MPM)

    Biological/Vaccine

    A xenogenic bone substitute is mixed with autologous platelet-rich plasma to form a mineralized plasmatic matrix, which serves as a control graft for ridge preservation after molar extraction.

Treatment groups

24 Participants
are divided into 2 treatment groups
Group A: Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)Experimental treatment 1 intervention
Group B: Mineralized Plasmatic Matrix (MPM)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in Alveolar Ridge Width

Measurement of horizontal bone width at the extraction site using cone-beam computed tomography (CBCT).

Time frame
Baseline (immediately postoperative) and 4 months postoperatively.

Secondary outcomes

1

Change in Alveolar Ridge Height

Measurement of vertical bone height at the extraction site using CBCT.

Time frame
Baseline (immediately postoperative) and 4 months postoperatively.
2

Change in Bone Density

Evaluation of bone density in the grafted socket area using CBCT grayscale values.

Time frame
Baseline (immediately postoperative) and 4 months postoperatively.
3

Postoperative Pain

Subjective evaluation of pain intensity at the surgical site using the Visual Analogue Scale (VAS).

Time frame
2 days, 1 week, and 1 month postoperatively.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: