Health TrialsbyHealthPanel

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures

ConditionsDiuretic EffectAminophyllineFurosemideCardiac Surgical Procedures
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorCairo University

About this trial

This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 18-65 years.

Both sexes.

All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).

Body mass index (BMI) ranged between 20 and 40 kg/m2.

Disqualifiers

Sensitivity or contraindication to Aminophylline or furosemide

Stage-5 chronic kidney disease (CKD) [Glomerular filtration rate (GFR) of less than 15 mL/min].

The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.

Recipients of dialysis before surgery.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Aminophylline

    Drug

    Patients will receive Aminophylline.

  • Furosemide

    Drug

    Patients will receive furosemide.

Treatment groups

106 Participants
are divided into 2 treatment groups
Group A: Aminophylline group (control group)Active comparator 1 intervention
Group B: Furosemide groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Measurement of urine output

Urine output will be measured at two hours after cardiopulmonary bypass.

Time frame
Two hours after cardiopulmonary bypass

Secondary outcomes

1

Measurement of urine output at completion of cardiopulmonary bypass

Urine output at completion of cardiopulmonary bypass (CPB) will be measured at 8 hours and 48 hours after CPB.

Time frame
48 hours after cardiopulmonary bypass
2

Urea level

Urea level will be measured at 8 hours and 48 hours after cardiopulmonary bypass.

Time frame
48 hours after cardiopulmonary bypass
3

Creatinine level

Creatinine level will be measured at 8 hours and 48 hours after cardiopulmonary bypass.

Time frame
48 hours after cardiopulmonary bypass
4

Lactate level

Lactate level will be measured at 8 hours and 48 hours after cardiopulmonary bypass.

Time frame
48 hours after cardiopulmonary bypass

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
Apply now