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Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

ConditionsTimeDexmedetomidineStress ResponseLaryngoscopyIntubation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorTanta University

About this trial

This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 18 to 65 years.

Both sexes.

American Society of Anesthesiology (ASA) physical status I-II.

Disqualifiers

Severe cardiovascular problems.

Respiratory disorders.

Diabetes.

Hypertension.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dexmedetomidine

    Drug

    Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.

  • Dexmedetomidine

    Drug

    Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.

  • Saline

    Drug

    Patients will receive saline before induction of anesthesia as a control group.

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: Group D20Experimental treatment 1 intervention
Group B: Group D10Experimental treatment 1 intervention
Group C: Group CPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Mean arterial pressure

Mean arterial pressure will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.

Time frame
Till the end of the surgery (Up to 2 hours)

Secondary outcomes

1

Heart rate

Heart rate will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.

Time frame
Till the end of the surgery (Up to 2 hours)
2

Need for intraoperative fentanyl

Need for intraoperative fentanyl will be recorded.

Time frame
Intraoperatively
3

Incidence of adverse events

Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, or any other complication.

Time frame
24 hours postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tanta University

Lead sponsor

Source ClinicalTrials.gov
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