Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

ConditionSpinal Cord Injuries (SCI)

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-75

SponsorMilap Sandhu

About this trial

This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.

Eligibility criteria

Qualifiers

Chronic Spinal Cord Injury (>6 months)

Motor incomplete SCI classified as AIS C or D

Volitional ankle plantarflexion strength in at least one leg

Disqualifiers

Uncontrolled hypertension (outside 140/90 and 90/60)

Concurrent medical illness

Traumatic brain injury

Cardiovascular complications

Trial design

Treatments tested in this trial

Sham AIH
Acute Intermittent Hypoxia (AIH) 15
Acute Intermittent Hypoxia (AIH) 23

Treatment groups

40 Participants

are divided into 3 treatment groups

Sponsors and collaborators

Milap Sandhu

Lead sponsor

Shirley Ryan AbilityLab

Sponsor institution

Shirley Ryan AbilityLab

Collaborator

Source ClinicalTrials.gov