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Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial

ConditionsCOPDMechanical VentilationWeaning From Mechanical Ventilation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-65
SponsorCairo University

About this trial

Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial

Disqualifiers

Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm

Trial population

Chronic obstructive pulmonary diseases undergoing breathing trial

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Doxapram

    Drug

    Doxapram will be given as 1.5 mg/kg will be given 10 minutes after the initiation of SBT

Treatment groups

35 Participants
are divided into 1 treatment group
Group A: Doxapram1 intervention

Trial outcomes

Primary outcomes

1

• Diaphragmatic excursion in mm

Time frame
before and 10 minutes after doxappram

Secondary outcomes

1

Arterial blood gases

Time frame
before and 10 minutes after doxapram
2

Respiratory rate

Time frame
before and 10 minutes after doxapram

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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