During Chest Surgery, One Lung is Isolated From Ventilation to Improve Visibility, With Carbon Dioxide Introduced Between the Lung and Chest Wall (Capnothorax): the Study Seeks to Optimize Ventilation Through Esophageal Pressure Measurement, Reducing Respiratory Complications.

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCardarelli Hospital

About this trial

The objective of this single-center observational study is to improve the safety and effectiveness of chest surgery through the use of a new ventilation technique. During the operation, to allow the surgeon to work more precisely, only one lung will receive air from the respirator. To improve visibility during surgery, a small amount of carbon dioxide is introduced into the space between the lung and the chest wall, a procedure called capnothorax. The aim of the research is to find the best way to set the patient's ventilation during the operation, ensuring adequate oxygenation and minimizing the risks to the lung. To do this, we will use a method of measuring the pressure inside the esophagus, which will allow us to better understand the status of the lungs and adjust ventilation accordingly. Esophageal pressure is an indirect measure of the pressure within the lung. By measuring this pressure, we can get important information about the status of the lungs and their ability to expand and contract. By measuring esophageal pressure, researchers will be able to set ventilation more precisely, optimizing the amount of air that is supplied to the lungs and the pressure inside the lungs themselves. This could help prevent lung damage and improve the patient's breathing during and after surgery, reducing respiratory complications and improving patients' quality of life.

General data collected at the beginning of the study and before the surgical intervention:

* date of birth, gender, weight, and height, * information and scores regarding the fitness for general anesthesia techniques, * anesthesia risk assessment made by the American Society of Anesthesiologists (ASA), * data related to respiratory mechanics.

Data collected during the surgical intervention:

* data related to respiratory mechanics measured at the ventilator, * data recorded by the optivent monitor to which the esophageal probe is connected, * hemodynamic data collected through a semi-invasive arterial blood pressure monitoring system, * arterial blood gas analysis, * pulmonary ultrasound findings.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age over 18 years • Patients to undergo robotic thoracic surgery with capnothorax

Disqualifiers

Pre-existing cardiac and/or pulmonary pathologies resulting in an ASA > 3

Contraindications to the placement of a nasogastric tube

Severe COPD (stage 3 or 4)

Emergency thoracotomy or sternotomy for surgical complications

Trial population

Patients from the AORN "Antonio Cardarelli" of Naples undergoing robotic thoracic surgery will be selected and will receive one-lung ventilation during general anesthesia with the capnothorax

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

36 Participants
are grouped into 1 trial group
Group A: CapnoPes

Trial outcomes

Primary outcomes

1

Evaluate the P/F ratio (PaO2/ FiO2), the driving pressure during the OLV phases in relation to the esophageal pressure.

Evaluate the P/F ratio (PaO2/ FiO2) and the driving pressure (the difference between plateau pressure and PEEP, during the OLV phases in relation to the esophageal pressure.

Time frame
from induction of general anesthesia to awakening

Secondary outcomes

1

P/F upon awakening from general anesthesia and evaluate postoperative respiratory complications

Evaluate the P/F upon awakening from general anesthesia and evaluate post-operative respiratory complications with the LUS score.The LUS (Lung Ultrasound Score) is a scoring system used to assess lung involvement. It is based on ultrasound images of the lungs, where different areas of the chest are evaluated for the presence of B-lines, consolidations, and other abnormalities. Each lung zone is scored, helping to classify the severity of the condition and monitor its clinical progression. This method is non-invasive and effective for real-time assessment.

Time frame
within 24 hours post-operatively

Other outcomes

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: