Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
ConditionSepsis and Septic Shock
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMenoufia University
About this trial
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using echocardiography (VTI) and cardiometry. We will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age > 18 years
Disqualifiers
Pregnancy
Significant valvular heart disease.
Atrial fibrillation.
Inadequate echocardiographic window.
Trial population
This single-center, prospective, observational study will be conducted in the Intensive Care Unit (ICU) at Menoufia University Hospitals. Adults spontaneously breathing patients with septic shock who undergo a fluid challenge as a part of their hemodynamic management in the first 24 hours will be eligible for enrollment. Ethical approval will be obtained from the ethics committee at the Menoufia Faculty of Medicine, and the study will follow ethical guidelines and secure approval from the Institutional Review Board (IRB). Written informed consent will be obtained from each participant or their legal surrogate before study inclusion.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
DeviceWe will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge.
Time frame
After 30 minsSecondary outcomes
1
Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
We will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.
Time frame
After 30 minsSponsors and contacts
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Source ClinicalTrials.gov