Dynamics of Wound Healing in Patients With Obesity
ConditionWound Healing
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity of Iowa
About this trial
Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug.
First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.
Eligibility criteria
Qualifiers
Be an adult who is having tissue taken from the roof of the mouth as part of a gum graft procedure.
Be able and willing to give informed consent on their own.
Have good oral hygiene (keep their teeth and gums clean).
Have a healthy roof of the mouth with no unusual shape, disease, or injury.
Disqualifiers
Are unable or unwilling to provide your own informed consent.
Take medications that may affect healing or require changes to the planned surgery.
Have a history of alcohol or drug abuse.
Currently smoke or have smoked in the past.
Trial design
Treatments tested in this trial
- Collagen Plug (standard of care)
- Platelet-Rich Fibrin Clot
Treatment groups
104 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov