Effect of a Nutritional Supplement on Muscle Recovery
ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age18-35
SponsorWageningen University
About this trial
The aim is to develop a food supplement drink that supports muscle health by combining specific fatty acids, which can positively affect metabolic and inflammation processes that are important for muscle health.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Young (≥18 and ≤35 years)
Male sex
Non-obese (≥18.5 and ≤27.5 kg/m2)
Recreationally active (performing non-competitive exercise at least one time a week for minimally 30 minutes)
Disqualifiers
Smoking
Participation in structural exercise with a major eccentric component (e.g. soccer, basketball, trail running, etc…)
Chronic use of any prescribed over the counter pharmaceuticals
Any history of medical or surgical events that may effect the study outcomes
Trial design
Design model
Parallel
Treatments tested in this trial
Control drink
Dietary supplementSeven day supplementation with a muscle damaging exercise performed on day four
Vegan supplement containing caprylic acid and omega-3 fatty acids
Dietary supplementSeven day supplementation with a muscle damaging exercise performed on day four
Treatment groups
28 Participants
are divided into 2 treatment groupsGroup A: TestdrinkExperimental treatment 1 intervention
Group B: Control drinkPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in isometric muscle strength of the vastus lateralis muscle on a muscle dynamometer before and 72h after damaging exercise
The main study endpoint is the change in skeletal muscle function recovery from a single bout of damaging eccentric exercise between an emulsion containing caprylic acid and omega 3 fatty acids, compared to a control emulsion, from before exercise (t=0) to 72 hours post-exercise. Skeletal muscle function will be measured as maximal voluntary isometric muscle strength of the vastus lateralis muscle on a muscle dynamometer. The maximal voluntary strength is expressed as maximal voluntary contraction (Newtons).
Time frame
The change in muscle strength will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.Secondary outcomes
1
Change in muscle fatigue from before until 72 hours after damaging exercise measured with electrical stimulation on a muscle dynamometer
The change in muscle fatigue recovery from a single bout of damaging eccentric exercise between an emulsion containing caprylic acid and omega 3 fatty acids compared to a control emulsion will be examined by means of a two-minute fatigue inducing protocol on a skeletal muscle dynamometer. Every other second during two minutes, electrically induced muscle contractions will be evoked on the vastus lateralis muscle at 40% of the maximal voluntary muscle strength. The percental decline in muscle force (N) generating capacity will be monitored as indicator of fatigue resistance.
Time frame
The change in fatigue resistance will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.2
Change in muscle soreness from before until up to 72 hours after a damaging exercise using a VAS-Scale and soreness questionnaire
The change in muscle soreness from a single bout of eccentric exercise between an emulsion containing caprylic acid and omega 3 fatty acids, compared to a control emulsion will be measured by means of a VAS-Scale, measuring current muscle soreness, as well as a retrospective pain questionnaire, measuring muscle soreness over the preceding 24 hours.
Time frame
The change in muscle soreness will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.3
Plasma creatine kinase concentrations before and up to 72 hours after damaging exercise in blood
The change in creatine kinase concentrations from a single bout of eccentric exercise between an emulsion containing caprylic acid and omega 3 fatty acids, compared to a control emulsion, will be measured using commercially available kits.
Time frame
The change in plasma creatine kinase will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.4
Plasma cholesterol concentrations before and up to 72 hours after damaging exercise in blood
The change in plasma cholesterol concentrations from a single bout of eccentric exercise between an emulsion containing caprylic acid and omega 3 fatty acids, compared to a control emulsion, will be measured using commercially available kits
Time frame
The change in plasma cholesterol concentrations will be measured at time points 0 hours (before exercise), and post exercise, and at 24 hours, 48 hours and 72 hours post exercise.Sponsors and contacts
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Source ClinicalTrials.gov