Health TrialsbyHealthPanel

Effect of Aerobic Interval Training on Atrial Fibrillation Burden

ConditionsAtrial FibrillationCardiac Rehabilitation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-74
SponsorNavy General Hospital, Beijing

About this trial

Atrial fibrillation is the most common arrhythmia, with an increasing incidence and prevalence, significantly increasing the risk of death, stroke, heart failure, cognitive impairment, and dementia, severely impacting the quality of life for patients and burdening society and healthcare systems. In recent years, exercise-based cardiac rehabilitation has gradually become a new approach for the treatment of patients with heart disease. The main research topics include: 1. Changes in atrial fibrillation burden in non-permanent atrial fibrillation patients after 12 weeks of HIIT(high-intensity interval training ) or MIIT (moderate-intensity interval training). 2. Changes in cardiorespiratory fitness, quality of life scores, mental health assessment scores, atrial strain, and left ventricular diastolic function in non-permanent atrial fibrillation patients after 12 weeks of aerobic interval training, along with follow-up on the occurrence of exercise-related adverse events and adverse cardiovascular events during the study period.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age range: 18-74 years;

Patients with non-permanent atrial fibrillation;

Resting heart rate ≤110 beats/min;

No history of receiving a formal exercise prescription within the past six months;

Disqualifiers

History of myocardial infarction, endocarditis/myocarditis/pericarditis, stroke (ischemic/hemorrhagic), pulmonary embolism, lower extremity venous thrombosis, or cardiac surgery within the past 6 months;

Moderate to severe pulmonary arterial hypertension, moderate to severe valvular heart disease, hypertrophic cardiomyopathy, aortic stenosis/dilation/dissection/intramural hematoma, congenital heart disease;

Heart failure (NYHA class III-IV) or acute exacerbation of heart failure within the past 3 months;

Unstable angina or severe coronary artery disease without revascularization;

Trial design

Design model

Parallel

Treatments tested in this trial

  • high-intensity interval training

    Other intervention

    high-intensity interval training ： 40-50 minutes, patients engage in power cycling with intervals of high-intensity exercise at 75%-100% of VO2peak for 30s-1min, followed by 30s-1min of passive recovery, totaling 15-25 cycles.

  • moderate-intensity interval training

    Other intervention

    40-50 minutes, involves power cycling with 8 minutes of moderate-intensity exercise at 40%-60% of VO2peak followed by 2 minutes of passive recovery, totaling 4 cycles.

Treatment groups

156 Participants
are divided into 3 treatment groups
Group A: High-intensity interval trainingExperimental treatment 1 intervention
Group B: moderate-intensity interval trainingExperimental treatment 1 intervention
Group C: Maintain previous exercise habits groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

atrial fibrillation burden

The ratio of atrial fibrillation duration to total monitoring time

Time frame
14 weeks

Secondary outcomes

1

Cardiorespiratory fitness

Peak oxygen consumption (VO2peak)

Time frame
14 weeks
2

Severity of atrial fibrillation symptoms

Atrial Fibrillation Symptom EHRA Score

Time frame
14 weeks
3

General quality of life assessment

SF-36 Quality of Life Questionnaire

Time frame
14 weeks
4

Prognostic indicators

MACE is defined as death, rehospitalization, cardiogenic shock, heart failure, new-onset malignant arrhythmias, stroke, and acute coronary syndrome

Time frame
14 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Navy General Hospital, Beijing

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: