Health TrialsbyHealthPanel

Effect of Exercise on Appetite in Response to Meals

ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age18-65
SponsorUniversity of Glasgow

About this trial

This clinical trial's primary aim is to investigate the acute effect of two exercise bouts (short \[10 minutes\] and long \[30 minutes\]) on appetite and appetite-regulatory hormone responses to a standard meal test. The secondary aim is to investigate when the changes in appetite and appetite-regulatory hormones occur during exercise. As an exploratory aim, the researchers will test if the two exercise bouts influence ad libitum energy intake in the periods after the standard meal test. The researchers will compare three groups (control, short exercise, and prolonged exercise) to see if the exercise bouts affect appetite, appetite-regulatory hormones, and energy intake in healthy men.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Males aged 18 years or older.

Have stable body mass for at least six months (within ±2 kg).

Disqualifiers

Females

People who are younger than 18 or older than 65 years old.

Have food allergies.

Have significant contraindications to exercise (e.g., an injury that would inhibit running).

Trial design

Design model

Crossover

Treatments tested in this trial

  • Bouts of Exercise

    Other intervention

    The participants will run on the treadmill for 10 minutes (short) or 30 minutes (prolonged).

Treatment groups

14 Participants
are divided into 3 treatment groups
Group A: ControlNo intervention 0 interventions
Group B: Short ExerciseExperimental treatment 1 intervention
Group C: Prolonged ExerciseExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in Peptide-YY (PYY)

Blood samples will be drawn at different time points during the trial to measure the change in PYY blood levels. Area under the plasma concentration versus time curve (AUC) of PYY will be calculated using the trapezoidal rule.

Time frame
At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours
2

Change in Ghrelin

Blood samples will be drawn at different time points during the trial to measure the change in ghrelin blood levels. Area under the plasma concentration versus time curve (AUC) of ghrelin will be calculated using the trapezoidal rule.

Time frame
At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours
3

Change in Glucagon-Like Peptide-1 (GLP-1)

Blood samples will be drawn at different time points during the trial to measure the change in GLP-1 blood levels. Area under the plasma concentration versus time curve (AUC) of GLP-1 will be calculated using the trapezoidal rule.

Time frame
At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours
4

Change in subjective appetite sensations

The subjective appetite sensations will be assessed using 100 mm visual analog scales (VAS) to measure appetite sensations (hunger, satiety, fullness, prospective food consumption, and desire to eat). The VAS are 100 mm long, with words anchored at each end expressing the most positive and negative ratings. Scores for each appetite construct range from 0-100.

Time frame
At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 5.5, and 6 hours

Secondary outcomes

1

Energy Intake

To determine the amount of each food item consumed, we will measure the difference in weight between before and after the meal. We will use manufacturer details to determine energy consumption.

Time frame
At 5 hours
2

Macro-nutrient Intake

To determine the amount of each food item consumed, we will measure the difference in weight between before and after the meal. We will use manufacturer details to determine macronutrient consumption

Time frame
At 5 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Glasgow

Lead sponsor

Northern Border University

Collaborator

Source ClinicalTrials.gov
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