About this trial

This study's primary aim is to investigate the acute effect of an exercise bout (30 minutes) on appetite and appetite-regulatory hormone responses during energy restriction. The researchers will also test if the exercise bout influences ad libitum energy intake after a period of energy restriction.

The researchers will compare three groups (control, severe-energy restriction, and severe-energy restriction with exercise) to see if exercise bout, during energy restriction, affects appetite, appetite-regulatory hormones, and energy intake in healthy men.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Males aged 18 years or older.

Have stable body mass for at least six months (within ±2 kg).

Disqualifiers

Females

People who are younger than 18 or older than 65 years old.

Following a special diet (e.g. weight loss, vegetarian or vegan, etc.).

Have food allergies related to the study.

Trial design

Design model

Crossover

Treatments tested in this trial

Severe-energy restriction
Other intervention
The participants will receive only 25% of their estimated energy needs.
Severe-energy restriction with exercise
Other intervention
The participants will run on the treadmill for 30 minutes and receive 25% of their estimated energy needs.

Treatment groups

14 Participants

are divided into 3 treatment groups

Group A: ControlNo intervention 0 interventions

Group B: Severe-energy restrictionExperimental treatment 1 intervention

Group C: Severe-energy restriction with exerciseExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in Peptide-YY (PYY)

The researchers will draw blood samples at different time points during the trial to measure the change in PYY blood levels. Area under the plasma concentration versus time curve (AUC) of PYY will be calculated using the trapezoidal rule.

Time frame

At 0 (baseline), 0.5, 1, 1.5, 2, 3, 4, 5, 5.5, 6, 6.5, 7, and 23 hours

2

Change in Ghrelin

The researchers will draw blood samples at different time points during the trial to measure the change in ghrelin blood levels. Area under the plasma concentration versus time curve (AUC) of ghrelin will be calculated using the trapezoidal rule.

Time frame

At 0 (baseline), 0.5, 1, 1.5, 2, 3, 4, 5, 5.5, 6, 6.5, 7, and 23 hours

3

Change in Glucagon-Like Peptide-1 (GLP-1)

The researchers will draw blood samples at different time points during the trial to measure the change in GLP-1 blood levels. Area under the plasma concentration versus time curve (AUC) of GLP-1 will be calculated using the trapezoidal rule.

Time frame

At 0 (baseline), 0.5, 1, 1.5, 2, 3, 4, 5, 5.5, 6, 6.5, 7, and 23 hours

4

Change in subjective appetite sensations

The researchers will assess the subjective appetite sensations using 100 mm visual analog scales (VAS) to measure appetite sensations (hunger, satiety, fullness, prospective food consumption, and desire to eat). The VAS are 100 mm long, with words anchored at each end expressing the most positive and negative ratings. Scores for each appetite construct range from 0-100.

Time frame

At 0 (baseline), 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 5.5, 6, 6.5, 7, 23, 24, and 25 hours

Secondary outcomes

1

Energy Intake

To determine the amount of each food item consumed, the researchers will measure the difference in weight between before and after the meal. The researchers will use manufacturer details to determine energy consumption.

Time frame

At 24 hours

2

Macro-nutrient Intake

To determine the amount of each food item consumed, the researchers will measure the difference in weight between before and after the meal. The researchers will use manufacturer details to determine macro-nutrient consumption.

Time frame

At 24 hours

Effect of Exercise on Appetite in Response to Meals During Energy Restriction

About this trial

Eligibility criteria

Qualifiers

Disqualifiers

Trial design

Treatments tested in this trial

Treatment groups

Trial outcomes

Primary outcomes

Secondary outcomes

Other outcomes

Sponsors and contacts