Health TrialsbyHealthPanel

Effect of Flax in Yogurt on Blood Cyanide Levels

ConditionHealthy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorSt. Boniface Hospital

About this trial

A randomized, controlled, cross-over post-prandial trial in healthy human volunteers will be conducted at the IH Asper Institute to determine the effect whole ground flaxseed, roasted then ground whole flaxseed, whole intact flaxseed and flaxseed hulls mixed into yogurt on blood cyanide levels.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Generally healthy adult, 18 years or older;

Willing to provide informed consent;

Willing/able to comply with the requirements of the study.

Disqualifiers

Pregnant or lactating;

Medical history of disease that is currently under treatment;

Active treatment for any type of cancer within 1 year prior to study start;

Presence of a gastrointestinal disorder, daily use of any stomach acid-lowering medications or laxatives (including fibre supplements) within the past month or antibiotic use within the past 6 weeks;

Trial design

Design model

Crossover

Treatments tested in this trial

  • 0 g Flax

    Dietary supplement

    175 g yogurt with no flax product

  • 40 g whole ground flaxseed

    Dietary supplement

    175 g yogurt with 40 g whole ground flaxseed

  • 40 g roasted then ground whole flaxseed

    Dietary supplement

    175 g yogurt with 40 g roasted then ground whole flaxseed

  • 40 g of whole intact flaxseeds

    Dietary supplement

    175 g yogurt with 40 g of whole intact flaxseeds

  • 28 g flax hulls

    Dietary supplement

    175 g yogurt with 28 g flax hulls

Treatment groups

12 Participants
are divided into 5 treatment groups
Group A: No Flax ProductOther 1 intervention
Group B: 40 g whole ground flaxseedExperimental treatment 1 intervention
Group C: 40 g roasted then ground whole flaxseedExperimental treatment 1 intervention
Group D: 40 g of whole intact flaxseedsExperimental treatment 1 intervention
Group E: 28 g flax hullsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Peak blood level of cyanide

highest concentration of cyanide during 180 min postprandial period

Time frame
180 minutes
2

iAUC blood cyanide

incremental area under the curve for cyanide from 0-180 min

Time frame
180 min

Secondary outcomes

1

Cyanogenic glycoside and thiocyanate concentrations in plasma and urine

Time frame
180 minutes

Other outcomes

1

Concentration of metabolites in blood and urine

Identification and concentration of metabolites in plasma and urine determined by LC-QTOF-MS

Time frame
180 minutes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

St. Boniface Hospital

Lead sponsor

Agriculture and Agri-Food Canada

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: