About this trial
This study will be conducted to investigate the effect of high- intensity interval training on insulin resistance in polycystic ovarian syndrome.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Obese women with polycystic Ovarian Syndrome (PCOS) as clinically diagnosed by the gynecologist.
Their ages will be ranged from 20 to 35 years old.
Their body mass index will be ranged from 30-40 kg/m2.
Their waist/hip ratio will be > 0.8.
Disqualifiers
Cushing syndrome, diabetes mellitus.
Thyroid dysfunction.
Hypothalamic amenorrhea, ovarian hyperplasia.
Respiratory, renal and liver dysfunction.
Trial design
Parallel
Treatments tested in this trial
Intermittent fasting diet group
Other interventionFasting for 14 hours and eating window for 10 hours (1400 kcal) as prescribed by nutrition specialist. Intermittent fasting is an approach of eating that focuses on when you eat rather than on what you eat. * During fasting hours (fasting window) the participants are allowed to drink water, tea, coffee and drinks without sugar. * During eating hours (eating window) the participants will follow 1400 kcal diet. * The diet targets recommended with respect to high intake of vegetables (3-4 serve daily), fruits (1-2 serve daily), fish, lean meats and poultry (3-4 serve daily), fat free and low fat dairy products (2-3 serve daily), and legumes, nuts and seeds (4-5 serves per week), carbohydrates (3-4 serve daily).
High intensity interval training
Other interventionAll participants will receive High intensity interval training program in the form of walking on the electronic treadmill for 40 min through 3 phases: Warm-up phase: included walking on the treadmill with light intensity (50% of maximal heart rate (MHR)) for 10 min, Actual phase: included walking on the treadmill with high intensity intervals (80-85% of MHR) repeated for 4 times, with 3-min active recovery at (70% of MHR) between intervals then Cool-downs phase: included walking on the treadmill with light intensity (50% of MHR) for 5 min for 12 weeks.
Treatment groups
Trial outcomes
Primary outcomes
Body weight
Body weight will be measured by using weight and height scale before and after treatment program.
Body mass index
It will be calculated by dividing weight in kilograms divided by height meter square.
Waist circumference
The waist circumference will be measured by tape measure from the narrowest point between the lower border of the ribcage and the iliac crest at the end of normal expiration.
Hip circumference
Hip circumference will be measured at the widest part of the hip using the tape measurement.
Secondary outcomes
Assessment of quality of life
Polycystic Ovary Syndrome Quality of Life scale (PCOSQ) will be used. It is composed of 26 items categorized into five sections: emotions (8 items), body hair (5 items), weight concerns (5 items), infertility concerns (4 items), and menstrual irregularities (4 items). Each item is scored with a seven-point. Like rating system where seven represents the best situation and 1 represents the worst situation. The sum of the total points in each item per domain will be evaluated. Ultimately, the first interval values (from 1 to \< 3 points) represent marked effects on health related quality of life (HRQOL); second interval values (from 3 to \< 4 points) represent the marginal effect on HRQOL; third interval values (from 4 to \< 5 points) represent the minimal effect on HRQOL; fourth interval (5 points) represents no effect on HRQOL.
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