Effect of Low Versus High Dialysate Sodium Concentration During Hemodialysis on Dialysis Recovery Time

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAlexandria University

About this trial

This research aims to assess the effect of low versus high dialysate sodium concentration during hemodialysis on dialysis recovery time

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with end-stage renal disease who have been prescribed long term hemodialysis and undergo four-hour HD treatments three times a week for more than 90 days.

Patient must be at least 18 years old. They must be able to read and write, as well as be in complete mental health.

Disqualifiers

Inability to complete the surveys due to reading or hearing difficulties, actual instability of clinical condition that necessitate hospitalization, dementia, active malignancy or liver failure.

Trial design

Design model

Parallel

Treatments tested in this trial

  • high dialysate Na

    Other intervention

    high dialysate sodium (Na = 141 mmol/L) for 8 weeks

  • low dialysate Na

    Other intervention

    low dialysate sodium (Na = 136 mmol/L) for 8 weeks

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: high dialysate NaExperimental treatment 1 intervention
Group B: low dialysate NaExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in dialysis recovery time

By assessing the patients' responses to the single open-ended question, "How long does it take you to recover from a dialysis session?"

Time frame
baseline, weeks 4 and 8

Secondary outcomes

1

Change in plasma sodium concentration

measuring plasma sodium concentration

Time frame
baseline, weeks 4 and 8
2

Change in the inter-dialytic weight gain

measuring the inter-dialytic weight gain

Time frame
8 weeks
3

Change in blood pressure (systolic, diastolic, mean)

measuring in blood pressure (systolic, diastolic, mean)

Time frame
8 weeks
4

Occurrence of intradialytic hypotension

incidence of intradialytic hypotension

Time frame
8 weeks

Other outcomes

Sponsors and contacts

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