Effect of Mandibular Drilling Speed on Implant Stability and Osteogenic Potential: A Randomized Clinical Trial

ConditionsEdentulism Tooth Loss

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age20-60

SponsorCairo University

About this trial

This randomized clinical trial aims to evaluate the effect of different low-speed biological drilling protocols on implant stability and the osteogenic potential of autogenous bone particles collected during implant osteotomy. Patients requiring single dental implant placement in the mandible will be randomly assigned to different drilling speed protocols without irrigation. Implant stability will be measured clinically, while collected bone particles will be analyzed for osteogenic markers. The study aims to determine whether biological drilling improves implant stability and preserves the regenerative potential of autogenous bone.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

Implant osteotomy using biological drilling at 50 rpm without irrigation.
Procedure/Surgery
Implant osteotomy will be performed using low-speed biological drilling at 50 rpm without irrigation. Bone particles produced during drilling will be collected for evaluation of osteogenic potential.
Implant osteotomy using biological drilling at 150 rpm without irrigation.
Procedure/Surgery
Implant osteotomy will be performed using biological drilling at 150 rpm without irrigation. Autogenous bone particles generated during drilling will be collected and analyzed for osteogenic potential.
Implant osteotomy using biological drilling at 300 rpm without irrigation.
Procedure/Surgery
Implant osteotomy will be performed using biological drilling at 300 rpm without irrigation with collection of autogenous bone particles for laboratory analysis.

Treatment groups

36 Participants

are divided into 3 treatment groups

Group A: 50 rpm Biological DrillingExperimental treatment 1 intervention

Group B: 150 rpm Biological DrillingExperimental treatment 1 intervention

Group C: 300 rpm Biological DrillingExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Implant Stability

Implant stability will be measured immediately after implant placement and 3 months postoperatively, using resonance frequency analysis (RFA). Implant stability will be recorded as an Implant Stability Quotient (ISQ) value to evaluate the mechanical stability of the implant in relation to the drilling speed used during osteotomy.

Time frame

At time of insertion and 3 months postoperatively.

Secondary outcomes

Osteogenic Potential of Autogenous Bone Particles

Autogenous bone particles generated during implant osteotomy will be collected and analyzed for osteogenic biomarkers associated with bone formation and regeneration. Laboratory analysis will include molecular assessment of osteogenic markers using ELISA and PCR techniques.

Time frame

Immediately after bone particle collection and subsequent laboratory analysis.

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: