Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKocaeli City Hospital
About this trial
Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium. Movement of the catheter tip due to respiratory changes can result in inadequate lesion formation and AF recurrence.
The success of AF ablation depends on the adequacy of energy delivered to the myocardium and the durability of pulmonary vein isolation (PVI). Poor energy delivery and tissue heating during ablation are a major cause of procedural failure in RFA. To improve the success of the PVI procedure, efforts are underway to optimize catheter stability and contact force. However, catheter force and stability are influenced by respiration-induced thoracic motion, highlighting the importance of controlled breathing for further optimization. Fluoroscopy and ablation times during electroanatomic mapping-guided AF ablations improved with controlled mechanical ventilation. General anesthesia improved catheter contact.
Low tidal volume, high respiratory rate (FCV), pressure controlled mechanical ventilation (PCV), volume controlled mechanical ventilation (VCV), pressure controlled volume assured mechanical ventilation (PRVC) can be used in investigators' hospital. The literature offers no definitive proof that one ablation procedure is superior to another.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Diagnosed with atrial fibrillation
planned to receive radiofrequency ablation treatment under general anesthesia
all patients over 18 years of age
Disqualifiers
None
Trial population
All ASA I-II-III patients over 18 years of age with a diagnosis of atrial fibrillation who were planned to receive radiofrequency ablation treatment under general anesthesia.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Radiofrequency Ablation with FCV.
Procedure/SurgeryTreatment of atrial fibrillation patients with radiofrequency ablation under general anesthesia with Flow Controlled Mechanical Ventilation (FCV).
Radiofrequency Ablation with VCV.
Procedure/SurgeryTreatment of atrial fibrillation patients with radiofrequency ablation under general anesthesia with Volume Controlled Mechanical Ventilation (VCV).
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Flow Controlled Mechanical Ventilation (FCV)1 intervention
Group B: Volume Controlled Mechanical Ventilation (VCV)1 intervention
Trial outcomes
Primary outcomes
1
Radiofrequency ablation procedure duration.
The effect of mechanical ventilation mode during radiofrequency ablation procedure on procedure duration.
Time frame
At the end of the ablation procedure (Ablation time varies between 1 and 3 hours)2
Change From Baseline Electrocardiography After Radiofrequency Ablation.
Change in baseline ECG during radiofrequency ablation procedure showing the effect of mechanical ventilation mode on procedural success.
Time frame
At the end of the ablation procedure (Ablation time varies between 1 and 3 hours)3
After radiofrequency ablation procedure atrial fibrillation recurrence rate.
The effect of mechanical ventilation mode during radiofrequency ablation procedure on atrial fibrillation recurrence rate.
Time frame
In one month after procedure.Sponsors and contacts
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Source ClinicalTrials.gov