Effect of Minoxidil Solution Iontophoresis on Androgenic Alopecia

ConditionAlopecia

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexMale

Age18-65

SponsorCairo University

About this trial

The aim of the study is to evaluate the therapeutic efficiency of minoxidil solution iontophoresis on Androgenic Alopecia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Twenty-five adult aged 18-65 with diagnosed androgenic alopecia.

They diagnosed as Androgenic alopeacia by their physicians and referred for physical therapy management.

Medically and psychologically stable patients.

Disqualifiers

History of hypersensitivity to minoxidil solution or Intophoresis.

Scalp infection

Concurrent hair loss treatments.

Patients who suffer from hypertrophic and/or keloidal scars and a skin condition in the area of Androgenic alopecia that would interfere with study procedures.

Trial design

Design model

Parallel

Treatments tested in this trial

Minoxidil solution iontophoresis
Other intervention
The half of the scalp of the participants will be treated with 5% minoxidil solution through Iontophoresis that will be applied at small low voltage (typically 10 V or less) continuous constant current (typically 0.5 mA/cm2 or less) to push a charged drug into skin or other tissue, twice daily at home.
saline solution iontophoresis
Other intervention
The other half of the scalp of the participants will be treated with placebo saline solution ( control) with the current application.

Treatment groups

25 Participants

are divided into 2 treatment groups

Group A: Minoxidil-treated scalpExperimental treatment 1 intervention

Group B: Saline-treated scalpActive comparator 1 intervention

Trial outcomes

Primary outcomes

Change in the number of hair follicles

Trichoscopy will be used to detect the change in the number of hair follicles as a comparison between before and after intervention. Trichoscopy helped with the definitive diagnosis of Alopeacia in patients for whom the clinical diagnosis was doubtful, which was confirmed by histopathology. Thus trichoscopy is a noninvasive, sensitive and specific investigation that is valuable in women with alopecia, the cause of which is otherwise very difficult to assess clinically, and it has a definite role in the diagnosis of cases with an atypical clinical picture.Trichoscopy results were obtained in frontal, occipital and both temporal areas of scalp, including number of yellow dots and vellus hairs, number of hairs in one pilosebaceous unit and percentage of follicular ostia with perifollicular hyperpigmentation.

Time frame

12 weeks

Secondary outcomes

Change of hair thickness

Global Photographic System will be used to detect the change of hair thickness as a comparison between before and after intervention. The Global Photographic Assessment is useful for determining overall clinical changes in a patient over times period in a standardized manner, Global Photographs are head shots taken a short distance away from the patients, a patient is usually photographed from the front, top, sides, and back to show accordingly a frontal hair line, crown, partition and vertex.

Time frame

12 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

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