Health TrialsbyHealthPanel

Effect of MOPs During Orthodontic Movement in Periodontitis Patients

ConditionsStage IV PeriodontitisOrthodontic Tooth Movement
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversidad Complutense de Madrid

About this trial

Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \<5mm)

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

adult patients older than 18-year-old;

systemically healthy (see

Disqualifiers

diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;

the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component <5mm) (experimental teeth);

in need of orthodontic therapy.

systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);

Trial design

Design model

Parallel

Treatments tested in this trial

  • Micro-ostoperforations (MOPs)

    Procedure/Surgery

    3 MOPs will be performed in the bone next to the root of the experimental tooth. MOPs will be performed using the Excellerator® (Propel Orthodontics, Denstply, Sirona)

Treatment groups

28 Participants
are divided into 2 treatment groups
Group A: Test groupExperimental treatment 1 intervention
Group B: Control groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

CAL

clinical attachment level (CAL) in mm

Time frame
12 months

Secondary outcomes

1

Type of movement

Description of the type of movement (categorical outcome)

Time frame
12 months
2

Duration of orthodontic treatment

Total duration in months

Time frame
>12 months
3

External apical root resorption (EARR)

Presence of EARR (in mm3)

Time frame
12 months
4

Probing pocket depth (PPD)

PPD in mm

Time frame
12 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Universidad Complutense de Madrid

Lead sponsor

Source ClinicalTrials.gov
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