Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-40
SponsorMinia University

About this trial

Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing.The success of root canal treatment is affected by the correct choice of clinical protocol.

These factors are dependent on the sanitization process (instrumentation, irrigating solution, irrigating strategies, and intracanal dressing) the apical limit of the root canal preparation and obturation, and the quality of the sealer. The challenges affecting the healing process of endodontically treated teeth include control of the inflammation of pulp or infectious processes and simultaneous neutralization of unpredictable provocations to the periapical tissue.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients with mature permanent teeth.

Patients with apical periodontitis.

Maxillary anterior teeth only will be involved.

Patients should be free from any systemic disease that may affect normal healing and predictable outcome.

Disqualifiers

Patients with immature canals.

Patients with swelling.

Pregnant females.

Patients who could/would not participate in a 1-year follow-up.

Trial design

Design model

Parallel

Treatments tested in this trial

  • AH plus sealer

    Procedure/Surgery

    to evaluate and compare postoperative pain and periapical healing after root canal treatment using two different base endodontic sealers: * NeoSEALER Flo * AH plus Resin sealer

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: AH plus sealerActive comparator 1 intervention
Group B: NeoSEALER FLOActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Treatment of Postoperative Pain

Patients will be evaluated for postoperative pain via (NRS) to record the intensity of pain.as follows: 0 reading represents "no pain" ; 1- 3 reading represents "mild pain" ; 4- 6 reading represents "moderate pain" and 7- 10 reading represents "severe pain".

Time frame
from 0 hours to 2 weeks after the procedure

Secondary outcomes

1

Periapical Healing

Periapical healing will be evaluated by comparing the size of the initial lesion pre-operatively and postoperatively (after 6 and 12 months), using periapical radiographs and CBCT. This will be aggregated in percentage (%).

Time frame
After 6 months to 12 months

Other outcomes

Sponsors and contacts

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