The goal of this clinical trial is to evaluate if molecular hydrogen can reduce the metabolic response during graded exercise in healthy women aged 18-30 years. The main questions it aims to answer are:
* Does molecular hydrogen reduce the respiratory exchange ratio? * Does molecular hydrogen reduce oxygen uptake?
Researchers will compare molecular hydrogen to a placebo (ambient air containing no molecular hydrogen) to see if molecular hydrogen reduces the metabolic response.
Participants will:
* Inhale molecular hydrogen for 60 minutes each day for 7 days. * Undergo an exercise testing twice after a two-week washout period.
Healthy female participants.
Regular menstrual cycle with exercise testing scheduled outside the menstrual phase.
Signed informed consent.
Pregnancy or breastfeeding.
History or presence of cardiovascular disease.
History or presence of respiratory disease.
Regular use of medications affecting metabolism.
Crossover
Molecular hydrogen
Other interventionGas mixture containing 3.75% molecular hydrogen and ambient air.
Placebo
Other interventionAmbient air without molecular hydrogen.
Respiratory exchange ratio
Respiratory exchange ratio is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Oxygen uptake
Oxygen uptake is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Carbon dioxide production
Carbon dioxide production is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Minute ventilation
Minute ventilation is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Breathing frequency
Breathing frequency is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Blood glucose concentration
Capillary blood glucose concentration is assessed at baseline (resting condition) and during the final minute of each exercise step using an Accu-Chek Inform II device (Roche Diagnostics, Manheim, Germany).
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