Clinical trials

This interventional study aims to assess self-sufficiency in patients with Parkinson's disease in the spa setting using the new Czech Functional Efficiency of Self-sufficiency Test (FEST) and to validate the test in this population. It also aims to evaluate changes in cognition, stability, fear of falling, and gait after specialized spa care and to analyze correlations between self-sufficiency and these outcomes.

This study protocol describes a prospective longitudinal observational study designed to evaluate the accuracy of machine learning models in predicting the short-term (24-72 h) risk of reduced participation (training modification or absence due to health complaints, injury, or illness) among elite youth football players (categories U16 to U19). Full participation in training and matches is a key determinant of athletic development and squad availability in elite youth football. Conventional injury surveillance typically reduces athlete availability to a binary time-loss state and overlooks the continuum on which athletes remain active despite emerging fatigue, minor musculoskeletal complaints, or functional limitations. In this study, continuous multimodal monitoring integrates external training and match locomotion (Catapult Vector 10 Hz GNSS / 100 Hz IMU), nocturnal autonomic nervous regulation (WHOOP 5.0 wrist-worn photoplethysmography evaluating resting heart rate, heart rate variability RMSSD, and sleep architecture), daily subjective wellness (AMS Hooper Index: sleep quality, stress, fatigue, mood, and muscle soreness), weekly neuromuscular screening (VALD ForceDecks countermovement jumps and NordBord hamstring strength), and anthropometrics with biological maturation offset. Participation status is adjudicated daily by designated coaching and medical staff. The primary objective is to develop, compare, and internally validate short-term prediction models for the onset transition from full participation to reduced participation, formulated as a single one-step discrete-time hazard read coherently across 24-, 48-, and 72-hour operational horizons. The study aims to evaluate explainable machine learning models (Survival XGBoost, GAMM with SHAP/LIME interpretation) to support training load management and injury risk mitigation within elite academies.

The purpose of this study is to determine whether drinking hydrogen-rich water can reduce fatigue and help football players maintain high-intensity physical activity during an official football match. The study will include 30 male football players competing in the second and third tiers of the Czech national football league system. Participants will be randomly assigned to drink either hydrogen-rich water or placebo water. Neither the players nor the researchers conducting the assessments will know which type of water each participant receives until the study has been completed. Participants will begin drinking the assigned water 72 hours before the match and will continue drinking it on match day. Players' physical activity and heart rate will be monitored throughout the match. The main outcome will be the distance covered at high intensity during consecutive 5-minute periods of the match. Repeated-sprint ability, jumping performance, and perceived muscle soreness will also be assessed before and after the match. The study will compare the hydrogen-rich water and placebo groups to determine whether hydrogen-rich water helps players maintain high-intensity activity during the match and reduces short-term fatigue after the match.

This study aims to evaluate the validity and reliability of a proposed plantar pressure assessment intrument based on an implementation of machine learning into optical pedography.

This study aims to evaluate the effectiveness of dry needling in patients with functional temporomandibular pain syndrome by comparing standard rehabilitation therapy alone with therapy combined with dry needling to reduce pain, improve jaw function and enhance quality of life.

The goal of this clinical trial is to evaluate whether hydrogen-rich water supplementation during tapering improves recovery after functional overreaching in competitive male basketball players aged 18-35 years. The main questions it aims to answer are: * Does hydrogen-rich water improve autonomic recovery after functional overreaching? * Does hydrogen-rich water improve recovery in biochemical, performance, and subjective feeling outcomes during tapering? Researchers will compare hydrogen-rich water to placebo (water containing no molecular hydrogen) to determine whether molecular hydrogen improves recovery after accumulated fatigue has been induced by functional overreaching. Participants will: * Complete a training cycle including normal training, functional overreaching, and tapering. * Consume hydrogen-rich or placebo water daily during the one-week tapering period. * Undergo repeated testing of autonomic nervous system, blood biochemical markers, performance, and subjective soreness.

The goal of this clinical trial is to evaluate if molecular hydrogen can reduce the metabolic response during graded exercise in healthy women aged 18-30 years. The main questions it aims to answer are: * Does molecular hydrogen reduce the respiratory exchange ratio? * Does molecular hydrogen reduce oxygen uptake? Researchers will compare molecular hydrogen to a placebo (ambient air containing no molecular hydrogen) to see if molecular hydrogen reduces the metabolic response. Participants will: * Inhale molecular hydrogen for 60 minutes each day for 7 days. * Undergo an exercise testing twice after a two-week washout period.

This Randomized Control Trial evaluates the impact of different gamification-based incentive schemes (levels, streaks and their combination) on adherence to target behaviors in children. Participants are randomized into four groups with different types of motivational frameworks.

This randomized, double-blind, placebo-controlled crossover trial will investigate the acute effects of sodium bicarbonate supplementation on performance, stroke biomechanics, and selected physiological and perceptual responses during a simulated 200-meter Bi-Fins race in elite finswimmers.