Effect of Sleep Extension in Prevention to Sleep Deprivation
ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorCentre Hospitalier Universitaire de Saint Etienne
About this trial
The approach of a competition can be associated to a decrease in sleep duration and quality which can negatively impact athlete's performance and health (injury risk, fall, accident). Ultra-endurance competitions even involve partial and/or total sleep deprivation over one or several nights. Studied investigating this question suggest that endurance performance under sleep deprivation is altered, mainly because of an effect on the rate of perceived exertion (RPE), which regulates effort intensity. One of the methods used by athletes to limit the impact of sleep deprivation in competition is to implement sleep extension in the days prior to a competition. However, few studies have investigated the impact of sleep deprivation et its reproducibility on performance and fatigue during a prolonged running exercise, as well as the efficiency of prior sleep extension. The importance of such a preventive measure might also depend on individual resistance to sleep deprivation, which is variable between persons and could have genetic determinants. This aspect remains under-studied, particularly regarding the impact of sleep deprivation on physical performance. Therefore, this study aims at investigating the effects of sleep deprivation and prior sleep extension on prolonged duration performance.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Volunteer who signed the written consent form.
Man or woman.
Aged 18-50.
Physically active and running at least one session of more than one hour per week.
Disqualifiers
- Any chronic pathology.
Working night shift.
Having sleep disorders: score > 5 at Pittsburg Sleep Quality Index.
Excessive sleepiness: score >10 at Epworth Sleepiness scale.
Trial design
Design model
Parallel
Treatments tested in this trial
Total sleep deprivation
Other interventionThis group will perform an incremental running test, conducted until exhaustion, in: - a control condition (usual sleep) - a one-night condition of partial sleep deprivation - a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.
partial sleep deprivation
Other interventionThis group will perform an incremental running test, conducted until exhaustion, in: - a control condition (usual sleep) - a one-night condition of partial sleep deprivation - a one-night partial sleep deprivation condition with 5 nights of prior extension. The order of conditions will be randomized.
Reproductibility
Other interventionThis group will perform an incremental running test, driven to exhaustion, after a night of total sleep deprivation twice, at least two weeks apart.
Treatment groups
69 Participants
are divided into 3 treatment groupsGroup A: REP (reproducibility).Experimental treatment 1 intervention
Group B: PT (total sleep deprivation).Experimental treatment 1 intervention
Group C: PP (partial sleep deprivation)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Performance over a standardized incremental running test
Sporting performance, measured by the duration of exercise in a time-limited incremental effort test in running to exhaustion, i.e. the inability to maintain the imposed pace.
Time frame
Day 7Secondary outcomes
1
Reproducibility of sleep deprivation effects.
Repeatability of sleep deprivation effects will be assessed within the REP group by comparing performance on the time limit test (in minutes) after each sleep deprivation.
Time frame
Day 72
Resistance to sleep deprivation and genetic polymorphism
The influence of genetic polymorphism will be evaluated via the effects of sleep deprivation according to the genetic polymorphism of the ADORA2A, TNFα and COMT genes
Time frame
DAy 13
Fatigue (objective and subjective, )
Neuromuscular fatigue will be assessed by the loss of isometric knee extensor muscle strength measured before and just after the time limit test. To characterize the origin of neuromuscular fatigue, electrically evoked forces from peripheral nerve stimulation and electrical muscle activity (EMG) will be measured to quantify central and peripheral fatigue.
Time frame
DAy 74
Fatigue (sleepiness)
Sleepiness will be assessed using the Epworth Sleepiness Scale, and perceived exertion will be rated on a Borg scale from 6 to 20 during submaximal exercise prior to the time limit test, and regularly during the test.
Time frame
DAy 7Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Centre Hospitalier Universitaire de Saint Etienne
Lead sponsor
Jean Monnet University
Collaborator
Source ClinicalTrials.gov