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Effect of Thymoquinone 0.2% Gel on Bone Density, Bone Width, and Socket Preservation After Tooth Extraction

ConditionsRadiographic EvaluationBone DensityBone WidthSocket PreservationTooth ExtractionThymoquinone
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorKafrelsheikh University

About this trial

This study aims to evaluate the clinical and radiographic effects of 0.2% Thymoquinone gel on bone density, bone width, and socket preservation after tooth extraction.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age: 18-50 years.

Both sexes.

Patients requiring extraction of upper posterior teeth will be recruited.

Disqualifiers

Healthy subjects with intact sockets after extraction.

Normal mouth opening and good oral hygiene.

No systemic conditions affecting bone healing.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Gel foam

    Drug

    Patients will receive gel foam only.

  • Thymoquinone gel + gel foam

    Drug

    Patients will receive 0.2% thymoquinone gel + gel foam.

  • Nano-formulated 0.2% thymoquinone gel + gel foam

    Drug

    Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.

Treatment groups

30 Participants
are divided into 3 treatment groups
Group A: Group I (Negative Control)Active comparator 1 intervention
Group B: Group II (Study Group 1)Experimental treatment 1 intervention
Group C: Group III (Study Group 2, Nano)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in alveolar bone density after tooth extraction

Alveolar bone density will be assessed radiographically using cone-beam computed tomography (CBCT). The change in bone density from baseline to the specified postoperative assessment will be compared.

Time frame
3 months after tooth extraction

Secondary outcomes

1

Change in alveolar bone width after tooth extraction

Alveolar bone width will be assessed radiographically using cone-beam computed tomography (CBCT). The change in alveolar ridge width from baseline to the postoperative assessment will be measured.

Time frame
3 months after tooth extraction
2

Change in alveolar ridge dimension after tooth extraction

Alveolar ridge dimensions will be assessed radiographically using cone-beam computed tomography (CBCT). Changes in the dimensions of the alveolar ridge following tooth extraction will be measured and compared.

Time frame
3 months after tooth extraction

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kafrelsheikh University

Lead sponsor

Source ClinicalTrials.gov
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