About this trial
The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation can affect blood flow in healthy volunteers. The main question it aims to answer is:
Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) inducing the most significant hyperaemic response in volunteers.
Participants will attend to one visit ( 1h30) , 6 protocol of stimulation will be tested on his arm . If his agree, an optionnal measure will be made during another visit. During this optionnal visit, two modalities of intensity adjustment will be tested in regard of the result of the first part of the study.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Subject aged 18 years or older
Having freely given written consent, after being informed of the purpose of the study, its conduct and its risks.
Affiliated with a social security scheme
Disqualifiers
Persons with pacemakers or any other implantable electrical devices,
Pregnant women
Suffering from dermatological conditions or muscle/skin lesions on the arms and forearms.
Participant unable to give free and informed consent.
Trial design
Single group
Treatments tested in this trial
transcutaneous electrical nerve stimulation
Other interventiontranscutaneous electrical nerve stimulation on arm. 6 different protocol will be apply testing different modality of frequency and positionnement of electrodes
Treatment groups
Trial outcomes
Primary outcomes
stimulation parameters that induce the most significant hyperaemic response
Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) that induce the most significant hyperaemic response in volunteers.
Secondary outcomes
Assess the score on a scale of disconfort level during stimulation for each condition
The outcome will be assess using a visual analogic disconfort scale ranging from 0 (no disconfort) to 10 (the highest disconfort imaginable).
Compare stimulation intensities between each condition
Compare muscle metabolic demand between each condition
Other outcomes
ancillary : Compare blood flow kinetics during long-term stimulation (1 hour) according to the modalities of intensity adjustment over time (no adjustment vs. adjustment).
ancillary : Compare the comfort reported by participants during long-term stimulation based on the methods used to adjust intensity over time (no adjustment vs. adjustment).
Sponsors and contacts
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Centre Hospitalier Metropole Savoie
Lead sponsor
Laboratoire Interuniversitaire de Biologie de la Motricité
Collaborator
Université Savoie Mont Blanc
Collaborator